This image shows cone photoreceptors directly contacting microglia within the outer plexiform layer of the human retina. The tissue was immunolabeled with antibodies against calbindin (green) and peanut agglutinin (blue), and microglia were labeled with monocyte marker ionized calcium-binding adapter molecule 1 (red). Microglia, photoreceptor interaction plays an important role in postnatal photoreceptor maturation, with loss of fractalkine-Cx3cr1 signaling leading to an altered distribution of cilium proteins, failure of outer segment elongation, and cone photoreceptor loss. For more information see the article by Jobling et al. (pages 4708–4723).