Research Articles, Neurobiology of Disease

Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα

Sujyoti Chandra, Malabendu Jana and Kalipada Pahan
Journal of Neuroscience 25 July 2018, 38 (30) 6682-6699; DOI: https://doi.org/10.1523/JNEUROSCI.0054-18.2018

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0054-18.2018
PubMed 
29967008
Published By 
Society for Neuroscience
History 
  • Received January 9, 2018
  • Revision received June 13, 2018
  • Accepted June 14, 2018
  • First published July 2, 2018.
  • Version of record published July 25, 2018.
Copyright & Usage 
Copyright © 2018 the authors 0270-6474/18/386682-18$15.00/0

Author Information

  1. Sujyoti Chandra1,
  2. Malabendu Jana1,2, and
  3. Kalipada Pahan1,2
  1. 1Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612 and
  2. 2Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612
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Author contributions

  1. Author contributions: S.C. wrote the first draft of the paper; K.P. edited the paper; S.C. and K.P. designed research; S.C. and M.J. performed research; S.C., M.J., and K.P. analyzed data; K.P. wrote the paper.

Disclosures

    • Received January 9, 2018.
    • Revision received June 13, 2018.
    • Accepted June 14, 2018.

  • This work was supported by the Department of Veteran Affairs (Merit Award I01BX002174), the Alzheimer's Association (Zenith Fellows Award ZEN-17-438829), and the National Institutes of Health (Grant AG050431).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Kalipada Pahan, Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St., Suite Cohn 310, Chicago, IL 60612. Kalipada_Pahan{at}rush.edu

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Jul 201814536280910
Aug 20182155179181
Sep 201882798110
Oct 20187939176
Nov 20185377842
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Total 2018193927801355
Jan 201953815174
Feb 20196029464
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Aug 20191336158
Oct 20192125134
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Total 20198442670665
Jan 20201723953
Feb 20201318142
Mar 20202318133
May 20202012232
Jun 20201312636
Jul 20201712533
Aug 202067614
Sep 20201113246
Oct 20201714747
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Jan 20231512523
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Mar 20231614656
Apr 2023199829
May 2023198839
Jun 2023282
Total 202380556184
Total2076683143416
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Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα
Sujyoti Chandra, Malabendu Jana, Kalipada Pahan
Journal of Neuroscience 25 July 2018, 38 (30) 6682-6699; DOI: 10.1523/JNEUROSCI.0054-18.2018
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  • Published on: (11 July 2018)
    Page navigation anchor for RE: Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα
    RE: Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα
    • Paolo Veronesi, researcher on rare diseases & orphan medicines, Worphmed Srl - World Orphan Medicines -

    Is there a good monitoring of gastric ulcers caused by the chronic use of ASA (brand Aspirin) ? Definitely not. I known many patients admitted to hospital for gastric bleeding after some weeks ASA treatment. Gastric bleeding means increased infections and infections means LPSs and further inflammation.
    Secondly : when Alzheimer's (AD) symptoms start and at which time AD candidate patient shall start to be treated with aSA ? There are different hypotheses and controversies about ad onset; some Authors indicate a range of 5-10 years before
    Third : what the recent hypotesis of the ling of AD and some strains of herpes virus ?
    Definitely, there could be the risk to add one of the several factors causing AD condition/progression.

    Competing Interests: None declared.