Article Information
- Received July 3, 2017
- Revision received May 23, 2018
- Accepted June 17, 2018
- First published June 29, 2018.
- Version of record published August 1, 2018.
Author Information
- R. Ross Welliver1,*,
- Jessie J. Polanco1,*,
- Richard A. Seidman1,
- Anjali K. Sinha1,
- Melanie A. O'Bara2,
- Zainab M. Khaku2,
- Diara A. Santiago González2,
- Akiko Nishiyama4,
- Jurgen Wess5,
- M. Laura Feltri1,3,
- Pablo M. Paez1,2, and
- Fraser J. Sim1,2
- 1Neuroscience Program,
- 2Department of Pharmacology and Toxicology, and
- 3Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, Center for Hearing and Deafness, University at Buffalo, Buffalo, New York 14214,
- 4Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, and
- 5Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
Author contributions
Author contributions: F.J.S. designed research; R.R.W., J.J.P., R.A.S., A.K.S., M.A.O., Z.M.K., D.A.S.G., M.L.F., P.M.P., and F.J.S. performed research; A.N. and J.W. contributed unpublished reagents/analytic tools; R.R.W., J.J.P., R.A.S., A.K.S., M.A.O., and F.J.S. analyzed data; R.R.W., J.J.P., and F.J.S. wrote the paper.
Disclosures
- Received July 3, 2017.
- Revision received May 23, 2018.
- Accepted June 17, 2018.
↵* R.R.W and J.J.P are co-first authors.
This work was supported by National Institute of Neurological Disorders and Stroke Grant R01NS104021, National Center for Advancing Translational Sciences UL1TR001412, National Multiple Sclerosis Society RG 5505-A-2 and RG 5110A1/1, the Kalec Multiple Sclerosis Foundation, the Change MS Foundation, the Skarlow Memorial Trust, and the Empire State Stem Cell Fund through New York State Department of Health Contract C028108. J.J.P. received additional support from National Institute of General Medical Sciences R25GM09545902 and National Center for Advancing Translational Sciences UL1TR001412-S1. The single-cell RNA-seq was performed by the Genomics Shared Resources at Roswell Park Cancer Institute, which is supported by National Institutes of Health/National Cancer Institute Grants P30 CA016056 (RPCI Cancer Center Support Grant). We thank the Confocal Microscope and Flow Cytometry Facility in the School of Medicine and Biomedical Sciences, University at Buffalo for assistance; and Ted Szczesny and Ed Hurley for assistance with electron microscopy.
The authors declare no competing financial interests.
- Correspondence should be addressed to Dr. Fraser J. Sim, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 3435 Main Street, Buffalo, NY 14214. fjsim{at}buffalo.edu
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