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Research Articles, Neurobiology of Disease

Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing

Aravindakshan Parthasarathy and Sharon G. Kujawa
Journal of Neuroscience 8 August 2018, 38 (32) 7108-7119; DOI: https://doi.org/10.1523/JNEUROSCI.3240-17.2018
Aravindakshan Parthasarathy
Department of Otolaryngology and Eaton–Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114
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Sharon G. Kujawa
Department of Otolaryngology and Eaton–Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3240-17.2018
PubMed 
29976623
Published By 
Society for Neuroscience
History 
  • Received November 13, 2017
  • Revision received June 27, 2018
  • Accepted June 28, 2018
  • First published July 5, 2018.
  • Version of record published August 8, 2018.
Copyright & Usage 
Copyright © 2018 the authors 0270-6474/18/387108-12$15.00/0

Author Information

  1. Aravindakshan Parthasarathy and
  2. Sharon G. Kujawa
  1. Department of Otolaryngology and Eaton–Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114
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Author contributions

  1. Author contributions: A.P. and S.G.K. designed research; A.P. performed research; A.P. analyzed data; A.P. and S.G.K. wrote the paper.

Disclosures

    • Received November 13, 2017.
    • Revision received June 27, 2018.
    • Accepted June 28, 2018.
  • This work was supported by the Department of Defense (Grant W81XWH-15-1-0103 to S.G.K.). We thank Eve Smith for technical support.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Sharon G. Kujawa, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St., Boston, MA 02114. Sharon_Kujawa{at}meei.harvard.edu

Other Version

  • previous version (July 05, 2018).
  • You are viewing the most recent version of this article.

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Jul 201816650112
Aug 20181183194120
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Dec 20181402518
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Jan 2019812524
Feb 2019554832
Mar 2019316741
Apr 20192811060
May 2019217460
Jun 2019145830
Jul 2019175231
Aug 2019526947
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Nov 2019245438
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Total 2019375690451
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Aug 202073219
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Apr 2021173426
May 2021135826
Jun 202164831
Jul 2021133722
Aug 2021126126
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Jan 2022294523
Feb 2022125728
Mar 2022104822
Apr 2022224635
May 2022114634
Jun 2022244239
Jul 2022153419
Aug 202295234
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Oct 2022218027
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Jan 2023104917
Feb 2023104822
Mar 2023165526
Apr 202384625
May 2023213236
Jun 2023103017
Jul 202364126
Aug 202354216
Sep 202373522
Total 202393378207
Total450129922017
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The Journal of Neuroscience: 38 (32)
Journal of Neuroscience
Vol. 38, Issue 32
8 Aug 2018
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Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing
Aravindakshan Parthasarathy, Sharon G. Kujawa
Journal of Neuroscience 8 August 2018, 38 (32) 7108-7119; DOI: 10.1523/JNEUROSCI.3240-17.2018

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Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing
Aravindakshan Parthasarathy, Sharon G. Kujawa
Journal of Neuroscience 8 August 2018, 38 (32) 7108-7119; DOI: 10.1523/JNEUROSCI.3240-17.2018
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Keywords

  • aging
  • auditory nerve
  • compensatory gain
  • EFR
  • hidden hearing loss
  • synaptopathy

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