Image of medial prefrontal cortex neurons in mice with neuropathic pain. Parvalbumin-positive interneurons (red) are co-labeled with the axon initial segment marker (Ankyrin-G, green) and the nuclear marker (DAPI; blue). Axon initial segments were shorter in animals with neuropathic pain, an effect that is reversed by treatment with certain analgesics. For more information, see the article Shiers, et al. (pages 7337–7350).