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PreviousNext
Cover ArticleResearch Articles, Systems/Circuits

Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus

Elham Jalalvand, Brita Robertson, Hervé Tostivint, Peter Löw, Peter Wallén and Sten Grillner
Journal of Neuroscience 29 August 2018, 38 (35) 7713-7724; DOI: https://doi.org/10.1523/JNEUROSCI.3359-17.2018
Elham Jalalvand
1The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden and
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Brita Robertson
1The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden and
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Hervé Tostivint
2Evolution des Régulations Endocriniennes, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique, and Muséum National d'Histoire Naturelle, Paris, France
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Peter Löw
1The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden and
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Peter Wallén
1The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden and
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Sten Grillner
1The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3359-17.2018
PubMed 
30037834
Published By 
Society for Neuroscience
History 
  • Received November 24, 2017
  • Revision received July 4, 2018
  • Accepted July 15, 2018
  • First published July 23, 2018.
  • Version of record published August 29, 2018.
Copyright & Usage 
Copyright © 2018 the authors 0270-6474/18/387713-12$15.00/0

Author Information

  1. Elham Jalalvand1,
  2. Brita Robertson1,
  3. Hervé Tostivint2,
  4. Peter Löw1,
  5. Peter Wallén1, and
  6. Sten Grillner1
  1. 1The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden and
  2. 2Evolution des Régulations Endocriniennes, Unité Mixte de Recherche 7221 Centre National de la Recherche Scientifique, and Muséum National d'Histoire Naturelle, Paris, France
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Author contributions

  1. Author contributions: E.J., B.R., P.W., and S.G. designed research; E.J., H.T., and P.L. performed research; E.J., B.R., P.L., and P.W. analyzed data; E.J., B.R., P.W., and S.G. wrote the paper.

Disclosures

    • Received November 24, 2017.
    • Revision received July 4, 2018.
    • Accepted July 15, 2018.
  • This work was supported by the Vetenskapsrådet (Grants VR-M-K2013-62X-03026, VR-M-2015-02816, and VR-NT-621-2013-4613), the European Union Seventh Framework Programme (FP7/2007-2013 Grant 604102 to H.B.P.), EU/Horizon 2020 Grant 720270 to H.B.P. specific grant agreement 1), StratNeuro Karolinska Institutet, the Karolinska Institutet's Research Funds, the Centre National de la Recherche Scientifique, and the Muséum National d'Histoire Naturelle. We thank Dr. Charlotta Borgius for assistance with the in situ hybridization and Dr. Liang Wang for conducting experiments on dopamine CSF-c neurons in the spinal cord that did not respond to deviations in pH.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Sten Grillner, The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Solnavägen 9, SE-171 77 Stockholm, Sweden. sten.grillner{at}ki.se

Other Version

  • previous version (July 23, 2018).
  • You are viewing the most recent version of this article.

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Jul 2018749044
Aug 20181138211133
Sep 2018108813082
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Apr 2019196691
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Jul 2021119122
Aug 2021107226
Sep 2021206335
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Total 20211211491271
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Total 202233312117
Total406856721783
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The Journal of Neuroscience: 38 (35)
Journal of Neuroscience
Vol. 38, Issue 35
29 Aug 2018
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Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus
Elham Jalalvand, Brita Robertson, Hervé Tostivint, Peter Löw, Peter Wallén, Sten Grillner
Journal of Neuroscience 29 August 2018, 38 (35) 7713-7724; DOI: 10.1523/JNEUROSCI.3359-17.2018

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Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus
Elham Jalalvand, Brita Robertson, Hervé Tostivint, Peter Löw, Peter Wallén, Sten Grillner
Journal of Neuroscience 29 August 2018, 38 (35) 7713-7724; DOI: 10.1523/JNEUROSCI.3359-17.2018
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Keywords

  • ASIC3
  • CSF-c neurons
  • hypothalamus
  • mechanosensor
  • pH sensor
  • somatostatin

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