Article Information
- Received August 11, 2017
- Revision received November 10, 2017
- Accepted November 28, 2017
- First published December 7, 2017.
- Version of record published January 24, 2018.
Author Information
- Ana Perez-Villalba1,2,3,
- M. Salomé Sirerol-Piquer1,2,3,
- Germán Belenguer1,2,3,
- Raúl Soriano-Cantón1,2,3,
- Ana Belén Muñoz-Manchado1,4,5,
- Javier Villadiego1,4,5,
- Diana Alarcón-Arís6,7,8,
- Federico N. Soria9,10,
- Benjamin Dehay9,10,
- Erwan Bezard9,10,
- Miquel Vila1,11,12,
- Analía Bortolozzi6,7,8,
- Juan José Toledo-Aral1,4,5,
- Francisco Pérez-Sánchez1,2,3, and
- Isabel Fariñas1,2,3
- 1Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, ISCIII, 28029 Madrid, Spain,
- 2Departamento de Biología Celular, Biología Funcional y Antropología Física and
- 3Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina, Universidad de Valencia, 46100 Burjassot, Spain,
- 4Departamento de Fisiología Médica y Biofísica and
- 5Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain,
- 6Department of Neurochemistry and Neuropharmacology, IIBB-CSIC and
- 7Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain,
- 8Centro de Investigación Biomédica en Red de Salud Mental, ISCIII, 28029 Madrid, Spain,
- 9Université de Bordeaux, Institut des Maladies Neurodégénératives, Unité Mixte de Recherche 5293 and
- 10Centre National de la Recherche Scientifique, Institut des Maladies Neurodégénératives, Unité Mixte de Recherche 5293, 33076 Bordeaux, France,
- 11Neurodegenerative Diseases Research Group, Vall d′Hebron Research Institute, Autonomous University of Barcelona, 08035, Barcelona, Spain, and
- 12Catalan Institution for Research and Advanced Studies, 08010 Barcelona, Spain
Author contributions
Author contributions: A.P.-V., M.S.S.-P., M.V., A.B., J.J.T.-A., F.P.-S., and I.F. designed research; A.P.-V., G.B., R.S.-C., A.B.M.-M., J.V., D.A.-A., and A.B. performed research; F.N.S., B.D., E.B., and M.V. contributed unpublished reagents/analytic tools; A.P.-V., M.S.S.-P., G.B., A.B., J.J.T.-A., F.P.-S., and I.F. analyzed data; I.F. wrote the paper.
Disclosures
- Received August 11, 2017.
- Revision received November 10, 2017.
- Accepted November 28, 2017.
This work was supported by Ministerio de Economía y Competitividad Spanish Grants SAF2014-54581 and SAF2016-77541 and Instituto de Salud Carlos III (PI12/02574, PI13/01390, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Centro de Investigación Biomédica en Red de Salud Mental and RETIC Tercel) to M.V., J.J.T-A., A.B., and I.F; Junta de Andalucía (Proyectos de Excelencia) to J.J.T-A.; Generalitat Valenciana (Programa Prometeo) to I.F.; European Regional Development Fund; and European Union (E.U.) to A.B. R.S.-C. and G.B. received Spanish Ministerio de Educación FPU predoctoral fellowships. Work in the I.F. laboratory is supported by Fundación Botín-Banco Santander. We thank Eva Porlan, Jose Manuel Morante-Redolat, and Sacri R. Ferrón for helpful discussions and scientific advice; Ma Ángeles Asensi for advice and help with the high-performance liquid chromatography coupled to tandem mass spectrometry analysis; Inmaculada Noguera and Ma José Palop for mouse care and veterinary advice; Servicio Central de Soporte a la Investigación Experimental (Universidad de Valencia); Ma Teresa Rávena for statistical advice; Ma Ángeles Marqués-Torrejón for help with the caspase-3 experiment; Brain Bank GIE NeuroCEB (BRIF 0033-00011), funded by the patients' associations France Alzheimer, France Parkinson, ARSEP, and “Connaître les Syndromes Cérébelleux,” the New York Brain Bank at Columbia University, and the University of Barcelona Brain Bank, for providing human postmortem samples; and the Michael J. Fox Foundation for the kind donation of the AAV5 carrying the human α-SYN.
The authors declare no competing financial interests.
- Correspondence should be addressed to either Dr. Isabel Fariñas or Dr. Francisco Pérez-Sánchez, Departamento de Biología Celular, Universidad de Valencia, Doctor Moliner 50, 46100 Burjassot, Spain. isabel.farinas{at}uv.es or pacops{at}uv.es
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