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Research Articles, Cellular/Molecular

Retinal Detachment-Induced Müller Glial Cell Swelling Activates TRPV4 Ion Channels and Triggers Photoreceptor Death at Body Temperature

Hidetaka Matsumoto, Shouta Sugio, François Seghers, David Krizaj, Hideo Akiyama, Yasuki Ishizaki, Philippe Gailly and Koji Shibasaki
Journal of Neuroscience 10 October 2018, 38 (41) 8745-8758; DOI: https://doi.org/10.1523/JNEUROSCI.0897-18.2018
Hidetaka Matsumoto
1Departments of Ophthalmology,
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Shouta Sugio
2Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan,
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François Seghers
3Laboratory of Cell Physiology, Institute of Neuroscience, Université catholique de Louvain, B-1200 Brussels, Belgium, and
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David Krizaj
4Department of Ophthalmology and Visual Sciences, Moran Eye Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132
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Hideo Akiyama
1Departments of Ophthalmology,
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Yasuki Ishizaki
2Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan,
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Philippe Gailly
3Laboratory of Cell Physiology, Institute of Neuroscience, Université catholique de Louvain, B-1200 Brussels, Belgium, and
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Koji Shibasaki
2Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0897-18.2018
PubMed 
30143574
Published By 
Society for Neuroscience
History 
  • Received April 9, 2018
  • Revision received August 21, 2018
  • Accepted August 21, 2018
  • First published August 24, 2018.
  • Version of record published October 10, 2018.
Copyright & Usage 
Copyright © 2018 Matsumoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hidetaka Matsumoto1,
  2. Shouta Sugio2,
  3. François Seghers3,
  4. David Krizaj4,
  5. Hideo Akiyama1,
  6. Yasuki Ishizaki2,
  7. Philippe Gailly3, and
  8. Koji Shibasaki2
  1. 1Departments of Ophthalmology,
  2. 2Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan,
  3. 3Laboratory of Cell Physiology, Institute of Neuroscience, Université catholique de Louvain, B-1200 Brussels, Belgium, and
  4. 4Department of Ophthalmology and Visual Sciences, Moran Eye Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132
View Full Text

Author contributions

  1. Author contributions: K.S. designed research; H.M., S.S., and K.S. performed research; H.M., F.S., D.K., H.A., Y.I., P.G., and K.S. contributed unpublished reagents/analytic tools; H.M., S.S., and K.S. analyzed data; H.M., D.K., P.G., and K.S. wrote the paper.

Disclosures

    • Received April 9, 2018.
    • Revision received August 21, 2018.
    • Accepted August 21, 2018.
  • This work was supported by the Global Ophthalmology Awards Program at Bayer (H.M.), a research grant for eye disease from Novartis (H.M.), and the Concerted Research Action from the General Direction of Scientific Research of the French Community of Belgium (ARC17/22-083 to P.G.). K.S. was supported by grants-in-aid for scientific research from the Takeda Science Foundation, the Sumitomo Foundation, the Brain Science Foundation, the Narishige Neuroscience Research Foundation, the Salt Science Research Foundation (Grant 14C2), the Ichiro Kanehara Foundation, and the MEXT/JSPS KAKENHI [Grants JP15H05934 (Thermal Biology), JP15H03000, JP18H03124, and JP18K19418]. We thank Y. Kogure (Gunma University, Maebashi, Japan) for technical assistance and our laboratory members for helpful discussions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Koji Shibasaki, Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan. shibasaki{at}gunma-u.ac.jp

Other Version

  • previous version (August 24, 2018).
  • You are viewing the most recent version of this article.

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Aug 2018762076
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Total 2021107478228
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Jun 202233110
Total 202248182110
Total308032541590
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The Journal of Neuroscience: 38 (41)
Journal of Neuroscience
Vol. 38, Issue 41
10 Oct 2018
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Retinal Detachment-Induced Müller Glial Cell Swelling Activates TRPV4 Ion Channels and Triggers Photoreceptor Death at Body Temperature
Hidetaka Matsumoto, Shouta Sugio, François Seghers, David Krizaj, Hideo Akiyama, Yasuki Ishizaki, Philippe Gailly, Koji Shibasaki
Journal of Neuroscience 10 October 2018, 38 (41) 8745-8758; DOI: 10.1523/JNEUROSCI.0897-18.2018

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Retinal Detachment-Induced Müller Glial Cell Swelling Activates TRPV4 Ion Channels and Triggers Photoreceptor Death at Body Temperature
Hidetaka Matsumoto, Shouta Sugio, François Seghers, David Krizaj, Hideo Akiyama, Yasuki Ishizaki, Philippe Gailly, Koji Shibasaki
Journal of Neuroscience 10 October 2018, 38 (41) 8745-8758; DOI: 10.1523/JNEUROSCI.0897-18.2018
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Keywords

  • glia
  • mechanical stimulus
  • retina
  • swelling
  • temperature
  • TRPV4

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