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Research Articles, Behavioral/Cognitive

Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance

Flavie Torrecillos, Gerd Tinkhauser, Petra Fischer, Alexander L. Green, Tipu Z. Aziz, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Keyoumars Ashkan, Peter Brown and Huiling Tan
Journal of Neuroscience 10 October 2018, 38 (41) 8905-8917; https://doi.org/10.1523/JNEUROSCI.1314-18.2018
Flavie Torrecillos
1Medical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH, Oxford, United Kingdom,
2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
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Gerd Tinkhauser
1Medical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH, Oxford, United Kingdom,
2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
3Department of Neurology, Bern University Hospital and University of Bern, 3010 Bern, Switzerland,
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Petra Fischer
1Medical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH, Oxford, United Kingdom,
2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
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Alexander L. Green
2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
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Tipu Z. Aziz
2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
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Thomas Foltynie
4Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, WC1N 3BG, London, United Kingdom, and
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Patricia Limousin
4Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, WC1N 3BG, London, United Kingdom, and
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Ludvic Zrinzo
4Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, WC1N 3BG, London, United Kingdom, and
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Keyoumars Ashkan
5Departments of Neurology and Neurosurgery, King's College Hospital, King's College London, SE5 9RS, London, United Kingdom
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Peter Brown
1Medical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH, Oxford, United Kingdom,
2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
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Huiling Tan
1Medical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH, Oxford, United Kingdom,
2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1314-18.2018
PubMed 
30181135
Published By 
Society for Neuroscience
History 
  • Received May 24, 2018
  • Revision received July 14, 2018
  • Accepted August 14, 2018
  • First published September 4, 2018.
  • Version of record published October 10, 2018.
Copyright & Usage 
Copyright © 2018 the authors 0270-6474/18/388905-13$15.00/0

Author Information

  1. Flavie Torrecillos1,2,
  2. Gerd Tinkhauser1,2,3,
  3. Petra Fischer1,2,
  4. Alexander L. Green2,
  5. Tipu Z. Aziz2,
  6. Thomas Foltynie4,
  7. Patricia Limousin4,
  8. Ludvic Zrinzo4,
  9. Keyoumars Ashkan5,
  10. Peter Brown1,2,*, and
  11. Huiling Tan1,2,*
  1. 1Medical Research Council Brain Network Dynamics Unit, University of Oxford, OX1 3TH, Oxford, United Kingdom,
  2. 2Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom,
  3. 3Department of Neurology, Bern University Hospital and University of Bern, 3010 Bern, Switzerland,
  4. 4Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, WC1N 3BG, London, United Kingdom, and
  5. 5Departments of Neurology and Neurosurgery, King's College Hospital, King's College London, SE5 9RS, London, United Kingdom
View Full Text

Author contributions

  1. Author contributions: F.T. wrote the first draft of the paper; F.T., G.T., P.F., P.B., and H.T. edited the paper; P.B. and H.T. designed research; P.F., A.L.G., T.Z.A., T.F., P.L., L.Z., K.A., and H.T. performed research; F.T., G.T., and H.T. analyzed data; F.T., P.B., and H.T. wrote the paper.

  2. ↵*P.B. and H.T. contributed equally to this study as joint senior authors.

Disclosures

    • Received May 24, 2018.
    • Revision received July 14, 2018.
    • Accepted August 14, 2018.
  • This work was supported by Medical Research Council MR/P012272/1 and MC_UU_12024/1, the Rosetrees Trust, and National Institute of Health Research Oxford Biomedical Research Centre. G.T. was also supported by the Swiss Parkinson Association.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Huiling Tan, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom. huiling.tan{at}ndcn.ox.ac.uk

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Sep 20189680108
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May 20251710628
Jun 20255307
Total 202570597179
Total476049972702
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The Journal of Neuroscience: 38 (41)
Journal of Neuroscience
Vol. 38, Issue 41
10 Oct 2018
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Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance
Flavie Torrecillos, Gerd Tinkhauser, Petra Fischer, Alexander L. Green, Tipu Z. Aziz, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Keyoumars Ashkan, Peter Brown, Huiling Tan
Journal of Neuroscience 10 October 2018, 38 (41) 8905-8917; DOI: 10.1523/JNEUROSCI.1314-18.2018

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Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance
Flavie Torrecillos, Gerd Tinkhauser, Petra Fischer, Alexander L. Green, Tipu Z. Aziz, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Keyoumars Ashkan, Peter Brown, Huiling Tan
Journal of Neuroscience 10 October 2018, 38 (41) 8905-8917; DOI: 10.1523/JNEUROSCI.1314-18.2018
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Keywords

  • beta bursts
  • beta oscillations
  • motor performance
  • Parkinson's disease
  • reaching movement
  • subthalamic nucleus

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