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Research Articles, Cellular/Molecular

CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity

Graeme S. Cottrell, Camille H. Soubrane, James A. Hounshell, Hong Lin, Venetia Owenson, Michael Rigby, Peter J. Cox, Bryan S. Barker, Matteo Ottolini, Selvi Ince, Claudia C. Bauer, Edward Perez-Reyes, Manoj K. Patel, Edward B. Stevens and Gary J. Stephens
Journal of Neuroscience 24 October 2018, 38 (43) 9186-9201; DOI: https://doi.org/10.1523/JNEUROSCI.3572-15.2018
Graeme S. Cottrell
1University of Reading, Whiteknights Campus, Reading RG6 6AJ, United Kingdom,
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Camille H. Soubrane
1University of Reading, Whiteknights Campus, Reading RG6 6AJ, United Kingdom,
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James A. Hounshell
3Departments of Anesthesiology,
5Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908
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Hong Lin
1University of Reading, Whiteknights Campus, Reading RG6 6AJ, United Kingdom,
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Venetia Owenson
2Pfizer Neuroscience and Pain Research Unit, Granta Park, Great Abington, Cambridge CB21 6GS, United Kingdom, and
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Michael Rigby
2Pfizer Neuroscience and Pain Research Unit, Granta Park, Great Abington, Cambridge CB21 6GS, United Kingdom, and
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Peter J. Cox
2Pfizer Neuroscience and Pain Research Unit, Granta Park, Great Abington, Cambridge CB21 6GS, United Kingdom, and
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Bryan S. Barker
3Departments of Anesthesiology,
5Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908
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Matteo Ottolini
3Departments of Anesthesiology,
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Selvi Ince
1University of Reading, Whiteknights Campus, Reading RG6 6AJ, United Kingdom,
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Claudia C. Bauer
1University of Reading, Whiteknights Campus, Reading RG6 6AJ, United Kingdom,
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Edward Perez-Reyes
4Pharmacology, and
5Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908
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  • ORCID record for Edward Perez-Reyes
Manoj K. Patel
3Departments of Anesthesiology,
5Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908
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Edward B. Stevens
2Pfizer Neuroscience and Pain Research Unit, Granta Park, Great Abington, Cambridge CB21 6GS, United Kingdom, and
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Gary J. Stephens
1University of Reading, Whiteknights Campus, Reading RG6 6AJ, United Kingdom,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3572-15.2018
PubMed 
30181139
Published By 
Society for Neuroscience
History 
  • Received September 22, 2015
  • Revision received June 3, 2018
  • Accepted June 13, 2018
  • First published September 4, 2018.
  • Version of record published October 24, 2018.
Copyright & Usage 
Copyright © 2018 the authors 0270-6474/18/389186-16$15.00/0

Author Information

  1. Graeme S. Cottrell1,*,
  2. Camille H. Soubrane1,*,
  3. James A. Hounshell3,5,
  4. Hong Lin1,
  5. Venetia Owenson2,
  6. Michael Rigby2,
  7. Peter J. Cox2,
  8. Bryan S. Barker3,5,
  9. Matteo Ottolini3,
  10. Selvi Ince1,
  11. Claudia C. Bauer1,
  12. Edward Perez-Reyes4,5,
  13. Manoj K. Patel3,5,
  14. Edward B. Stevens2, and
  15. Gary J. Stephens1
  1. 1University of Reading, Whiteknights Campus, Reading RG6 6AJ, United Kingdom,
  2. 2Pfizer Neuroscience and Pain Research Unit, Granta Park, Great Abington, Cambridge CB21 6GS, United Kingdom, and
  3. 3Departments of Anesthesiology,
  4. 4Pharmacology, and
  5. 5Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908
View Full Text

Author contributions

  1. Author contributions: G.S.C., C.H.S., J.A.H., P.J.C., E.P.-R., M.K.P., E.B.S., and G.J.S. designed research; G.S.C., C.H.S., J.A.H., H.L., V.O., B.S.B., M.O., S.I., C.C.B., and M.K.P. performed research; P.J.C., E.P.-R., E.B.S., and G.J.S. contributed unpublished reagents/analytic tools; G.S.C., C.H.S., J.A.H., H.L., M.R., B.S.B., and M.K.P. analyzed data; C.H.S., M.K.P., E.B.S., and G.J.S. wrote the paper.

  2. ↵*G.S.C. and C.H.S. contributed equally to this work.

View Abstract

Disclosures

    • Received September 22, 2015.
    • Revision received June 3, 2018.
    • Accepted June 13, 2018.
  • This work was supported by a Biotechnology and Biological Sciences Research Council Departmental Training Grant with a CASE Award from Pfizer UK to G.J.S. and E.B.S. to support C.H.S. This work was also supported by National Institutes of Health (NIH)/NINDS Grant NS-075157 to M.K.P. and NIH Grant NS-069524 to E.P.R.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Gary J. Stephens, School of Pharmacy, University of Reading, Whiteknights, P.O. Box 228, Reading RG6 6AJ, UK, g.j.stephens{at}reading.ac.uk; or Edward B. Stevens, Metrion Biosciences Ltd., Riverside 3, Granta Park, Great Abington, Cambridge CB21 6AD, UK, edward.stevens{at}metrionbiosciences.com

Other Version

  • previous version (September 04, 2018).
  • previous version (September 04, 2018).
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The Journal of Neuroscience: 38 (43)
Journal of Neuroscience
Vol. 38, Issue 43
24 Oct 2018
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CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity
Graeme S. Cottrell, Camille H. Soubrane, James A. Hounshell, Hong Lin, Venetia Owenson, Michael Rigby, Peter J. Cox, Bryan S. Barker, Matteo Ottolini, Selvi Ince, Claudia C. Bauer, Edward Perez-Reyes, Manoj K. Patel, Edward B. Stevens, Gary J. Stephens
Journal of Neuroscience 24 October 2018, 38 (43) 9186-9201; DOI: 10.1523/JNEUROSCI.3572-15.2018

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CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity
Graeme S. Cottrell, Camille H. Soubrane, James A. Hounshell, Hong Lin, Venetia Owenson, Michael Rigby, Peter J. Cox, Bryan S. Barker, Matteo Ottolini, Selvi Ince, Claudia C. Bauer, Edward Perez-Reyes, Manoj K. Patel, Edward B. Stevens, Gary J. Stephens
Journal of Neuroscience 24 October 2018, 38 (43) 9186-9201; DOI: 10.1523/JNEUROSCI.3572-15.2018
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Keywords

  • CACHD1
  • CaV3 calcium channel
  • T-type calcium current
  • α2δ auxiliary subunit

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