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Featured ArticleResearch Articles, Development/Plasticity/Repair

Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity

Daire Rowlands, Kristian K. Lensjø, Tovy Dinh, Sujeong Yang, Melissa R. Andrews, Torkel Hafting, Marianne Fyhn, James W. Fawcett and Gunnar Dick
Journal of Neuroscience 21 November 2018, 38 (47) 10102-10113; https://doi.org/10.1523/JNEUROSCI.1122-18.2018
Daire Rowlands
1John van Geest Centre for Brain Repair, University of Cambridge, Robinson Way, Cambridge CB2 0PY, United Kingdom,
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Kristian K. Lensjø
2Department of Biosciences, University of Oslo, 0316 Oslo, Norway,
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Tovy Dinh
4Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway, and
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Sujeong Yang
1John van Geest Centre for Brain Repair, University of Cambridge, Robinson Way, Cambridge CB2 0PY, United Kingdom,
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Melissa R. Andrews
3Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom,
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Torkel Hafting
2Department of Biosciences, University of Oslo, 0316 Oslo, Norway,
4Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway, and
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Marianne Fyhn
2Department of Biosciences, University of Oslo, 0316 Oslo, Norway,
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James W. Fawcett
1John van Geest Centre for Brain Repair, University of Cambridge, Robinson Way, Cambridge CB2 0PY, United Kingdom,
5Centre for Reconstructive Neuroscience, Institute for Experimental Medicine CAS, Prague, Czech Republic
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Gunnar Dick
2Department of Biosciences, University of Oslo, 0316 Oslo, Norway,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1122-18.2018
PubMed 
30282728
Published By 
Society for Neuroscience
History 
  • Received May 4, 2018
  • Revision received August 31, 2018
  • Accepted September 20, 2018
  • First published October 3, 2018.
  • Version of record published November 21, 2018.
Copyright & Usage 
Copyright © 2018 the authors 0270-6474/18/3810102-12$15.00/0

Author Information

  1. Daire Rowlands1,*,
  2. Kristian K. Lensjø2,*,
  3. Tovy Dinh4,
  4. Sujeong Yang1,
  5. Melissa R. Andrews3,
  6. Torkel Hafting2,4,
  7. Marianne Fyhn2,
  8. James W. Fawcett1,5, and
  9. Gunnar Dick2
  1. 1John van Geest Centre for Brain Repair, University of Cambridge, Robinson Way, Cambridge CB2 0PY, United Kingdom,
  2. 2Department of Biosciences, University of Oslo, 0316 Oslo, Norway,
  3. 3Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom,
  4. 4Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway, and
  5. 5Centre for Reconstructive Neuroscience, Institute for Experimental Medicine CAS, Prague, Czech Republic
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Author contributions

  1. D.R., K.K.L., T.D., S.Y., M.R.A., T.H., M.F., J.W.F., and G.D. designed research; D.R., K.K.L., T.D., S.Y., M.R.A., T.H., M.F., and G.D. performed research; M.R.A., J.W.F., and G.D. contributed unpublished reagents/analytic tools; D.R., K.K.L., T.D., S.Y., T.H., and M.F. analyzed data; D.R., K.K.L., M.F., and G.D. wrote the paper.

  2. ↵*D.R. and K.K.L. contributed equally to this work.

Disclosures

    • Received May 4, 2018.
    • Revision received August 31, 2018.
    • Accepted September 20, 2018.
  • This work was funded by Alzheimer's Research UK (Grant ARUK-RF2016A-1), the Christopher and Dana Reeve Foundation, the Research Council of Norway (Grants 143543, 143730, and 549217 to M.F.; and 231248 to T.H.), and the University of Oslo. We thank Dr. Connor Quinn for assistance with image analysis, Tove Klungervik and Bård Enger Mathisen for assistance with genotyping, and Rune A. Lanton for technical assistance for imaging of optical intrinsic signals.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Gunnar Dick, Department of Biosciences, University of Oslo, P.O. Box 1066, 0316 Oslo, Norway. gunnar.dick{at}mn.uio.no

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The Journal of Neuroscience: 38 (47)
Journal of Neuroscience
Vol. 38, Issue 47
21 Nov 2018
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Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity
Daire Rowlands, Kristian K. Lensjø, Tovy Dinh, Sujeong Yang, Melissa R. Andrews, Torkel Hafting, Marianne Fyhn, James W. Fawcett, Gunnar Dick
Journal of Neuroscience 21 November 2018, 38 (47) 10102-10113; DOI: 10.1523/JNEUROSCI.1122-18.2018

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Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity
Daire Rowlands, Kristian K. Lensjø, Tovy Dinh, Sujeong Yang, Melissa R. Andrews, Torkel Hafting, Marianne Fyhn, James W. Fawcett, Gunnar Dick
Journal of Neuroscience 21 November 2018, 38 (47) 10102-10113; DOI: 10.1523/JNEUROSCI.1122-18.2018
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Keywords

  • aggrecan
  • inhibitory
  • interneuron
  • neuronal plasticity
  • parvalbumin
  • perineuronal nets

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