This 3D-reconstructed confocal image shows GFAP+CA1 hippocampal astrocytes in a mouse that exhibited spontaneous unprovoked recurrent seizures after repetitive diffuse mild traumatic brain injury. The seizures were associated with early and sustained loss of glutamate transporter 1 expression in atypical astrocytes. For more details, see the article by Shandra et al. (pages 1944–1963).