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Research Articles, Behavioral/Cognitive

Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production

Anna Chrabaszcz, Wolf-Julian Neumann, Otilia Stretcu, Witold J. Lipski, Alan Bush, Christina A. Dastolfo-Hromack, Dengyu Wang, Donald J. Crammond, Susan Shaiman, Michael W. Dickey, Lori L. Holt, Robert S. Turner, Julie A. Fiez and R. Mark Richardson
Journal of Neuroscience 3 April 2019, 39 (14) 2698-2708; https://doi.org/10.1523/JNEUROSCI.2842-18.2019
Anna Chrabaszcz
1Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213,
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Wolf-Julian Neumann
2Movement Disorder and Neuromodulation Unit, Department of Neurology, Campus Mitte, Charité, Universitätsmedizin Berlin, Berlin, Germany 10117,
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Otilia Stretcu
3Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213,
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Witold J. Lipski
4Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,
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Alan Bush
4Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,
5Department of Physics, FCEN, University of Buenos Aires and IFIBA-CONICET, Buenos Aires, Argentina 1428,
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Christina A. Dastolfo-Hromack
4Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,
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Dengyu Wang
4Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,
6School of Medicine, Tsinghua University, Beijing, China 100084,
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Donald J. Crammond
4Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,
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Susan Shaiman
7Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania 15213,
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Michael W. Dickey
7Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania 15213,
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  • ORCID record for Michael W. Dickey
Lori L. Holt
8Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213,
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Robert S. Turner
9Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, and
10University of Pittsburgh Brain Institute, Pittsburgh, Pennsylvania 15213
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Julie A. Fiez
1Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213,
7Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania 15213,
10University of Pittsburgh Brain Institute, Pittsburgh, Pennsylvania 15213
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R. Mark Richardson
4Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,
9Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, and
10University of Pittsburgh Brain Institute, Pittsburgh, Pennsylvania 15213
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2842-18.2019
PubMed 
30700532
Published By 
Society for Neuroscience
History 
  • Received November 5, 2018
  • Revision received January 11, 2019
  • Accepted January 18, 2019
  • First published January 30, 2019.
  • Version of record published April 3, 2019.
Copyright & Usage 
Copyright © 2019 the authors

Author Information

  1. Anna Chrabaszcz1,
  2. Wolf-Julian Neumann2,
  3. Otilia Stretcu3,
  4. Witold J. Lipski4,
  5. Alan Bush4,5,
  6. Christina A. Dastolfo-Hromack4,
  7. Dengyu Wang4,6,
  8. Donald J. Crammond4,
  9. Susan Shaiman7,
  10. Michael W. Dickey7,
  11. Lori L. Holt8,
  12. Robert S. Turner9,10,
  13. Julie A. Fiez1,7,10, and
  14. R. Mark Richardson4,9,10
  1. 1Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213,
  2. 2Movement Disorder and Neuromodulation Unit, Department of Neurology, Campus Mitte, Charité, Universitätsmedizin Berlin, Berlin, Germany 10117,
  3. 3Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213,
  4. 4Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213,
  5. 5Department of Physics, FCEN, University of Buenos Aires and IFIBA-CONICET, Buenos Aires, Argentina 1428,
  6. 6School of Medicine, Tsinghua University, Beijing, China 100084,
  7. 7Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, Pennsylvania 15213,
  8. 8Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213,
  9. 9Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, and
  10. 10University of Pittsburgh Brain Institute, Pittsburgh, Pennsylvania 15213
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Author contributions

  1. Author contributions: A.C. wrote the first draft of the paper; A.C., W.-J.N., O.S., W.J.L., A.B., C.A.D.-H., D.W., D.J.C., S.S., M.W.D., L.L.H., R.S.T., J.A.F., and R.M.R. edited the paper; A.C., W.J.L., C.A.D.-H., S.S., M.W.D., L.L.H., R.S.T., J.A.F., and R.M.R. designed research; A.C., W.J.L., C.A.D.-H., D.J.C., and R.M.R. performed research; A.C., W.-J.N., O.S., W.J.L., A.B., D.W., J.A.F., and R.M.R. analyzed data; A.C. wrote the paper.

Disclosures

    • Received November 5, 2018.
    • Revision received January 11, 2019.
    • Accepted January 18, 2019.
  • This work was supported by the National Institute of Neurological Disorders and Stroke–National Institutes of Health (Grant U01NS098969 to R.M.R.), the Hamot Health Foundation (R.M.R.), and a University of Pittsburgh Brain Institute NeuroDiscovery Pilot Research Award (R.M.R.). We thank the patients who participated in this study and the clinical staff who facilitated data collection.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to R. Mark Richardson at richardsonrm{at}upmc.edu

Other Version

  • previous version (January 30, 2019).
  • You are viewing the most recent version of this article.

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Jan 2019441013
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Jul 202556814
Aug 202596427
Sep 2025156126
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Total 2025110652205
Total677549012114
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The Journal of Neuroscience: 39 (14)
Journal of Neuroscience
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3 Apr 2019
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Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production
Anna Chrabaszcz, Wolf-Julian Neumann, Otilia Stretcu, Witold J. Lipski, Alan Bush, Christina A. Dastolfo-Hromack, Dengyu Wang, Donald J. Crammond, Susan Shaiman, Michael W. Dickey, Lori L. Holt, Robert S. Turner, Julie A. Fiez, R. Mark Richardson
Journal of Neuroscience 3 April 2019, 39 (14) 2698-2708; DOI: 10.1523/JNEUROSCI.2842-18.2019

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Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production
Anna Chrabaszcz, Wolf-Julian Neumann, Otilia Stretcu, Witold J. Lipski, Alan Bush, Christina A. Dastolfo-Hromack, Dengyu Wang, Donald J. Crammond, Susan Shaiman, Michael W. Dickey, Lori L. Holt, Robert S. Turner, Julie A. Fiez, R. Mark Richardson
Journal of Neuroscience 3 April 2019, 39 (14) 2698-2708; DOI: 10.1523/JNEUROSCI.2842-18.2019
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Keywords

  • deep brain stimulation
  • electrocorticography
  • Parkinson's disease
  • sensorimotor cortex
  • speech
  • subthalamic nucleus

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