Article Information
- Received May 7, 2018
- Revision received December 24, 2018
- Accepted January 21, 2019
- First published February 12, 2019.
- Version of record published April 17, 2019.
Author Information
- Albert Snowball1,*,
- Elodie Chabrol1,*,
- Robert C. Wykes1,*,
- Tawfeeq Shekh-Ahmad1,*,
- Jonathan H. Cornford1,
- Andreas Lieb1,
- Michael P. Hughes2,
- Giulia Massaro2,
- Ahad A. Rahim2,
- Kevan S. Hashemi3,
- Dimitri M. Kullmann1,
- Matthew C. Walker1, and
- Stephanie Schorge1
- 1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
- 2UCL School of Pharmacy, University College London, London WC1N 1AX, United Kingdom, and
- 3Open Source Instruments Inc., Watertown, Massachusetts 02472
Author contributions
Author contributions: A.S., R.C.W., D.M.K., M.C.W., and S.S. designed research; A.S., E.C., R.C.W., T.S.-A., A.L., and K.S.H. performed research; M.P.H., G.M., A.A.R., and K.S.H. contributed unpublished reagents/analytic tools. A.S., E.C., R.C.W., J.H.C., A.L., K.S.H., D.M.K., M.C.W., and S.S. analyzed data; A.S. and D.M.K. wrote the paper.
↵*A.S., E.C., R.C.W., and T.S.-A. contributed equally to this work.
Disclosures
- Received May 7, 2018.
- Revision received December 24, 2018.
- Accepted January 21, 2019.
This work was supported by the Medical Research Council, the Wellcome Trust, Epilepsy Research UK, a Marie Skłodowska-Curie Actions Research Fellowship, and a Royal Society University Research Fellowship. We thank G. Schiavo (UCL Institute of Neurology) for the gift of TeNT, S. Hart (UCL Institute of Child Health) for the Neuro-2a cells, and A.J. Thrasher and W. Qasim (UCL Institute of Child Health) for the pMDG-VSV.G and pCMVdR8.74D64V plasmids. We also thank the members of our Biological Services Unit for the animal care provided.
The authors have intellectual property on the use of engineered potassium channels. K.S.H. is the majority share-holder of Open Source Instruments, Inc. The authors declare no other competing financial interests.
- Correspondence should be addressed to Dimitri M. Kullmann at d.kullmann{at}ucl.ac.uk or Matthew C. Walker at m.walker{at}ucl.ac.uk
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