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Research Articles, Neurobiology of Disease

Epilepsy Gene Therapy Using an Engineered Potassium Channel

Albert Snowball, Elodie Chabrol, Robert C. Wykes, Tawfeeq Shekh-Ahmad, Jonathan H. Cornford, Andreas Lieb, Michael P. Hughes, Giulia Massaro, Ahad A. Rahim, Kevan S. Hashemi, Dimitri M. Kullmann, Matthew C. Walker and Stephanie Schorge
Journal of Neuroscience 17 April 2019, 39 (16) 3159-3169; DOI: https://doi.org/10.1523/JNEUROSCI.1143-18.2019
Albert Snowball
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Elodie Chabrol
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Robert C. Wykes
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Tawfeeq Shekh-Ahmad
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Jonathan H. Cornford
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Andreas Lieb
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Michael P. Hughes
2UCL School of Pharmacy, University College London, London WC1N 1AX, United Kingdom, and
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Giulia Massaro
2UCL School of Pharmacy, University College London, London WC1N 1AX, United Kingdom, and
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Ahad A. Rahim
2UCL School of Pharmacy, University College London, London WC1N 1AX, United Kingdom, and
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Kevan S. Hashemi
3Open Source Instruments Inc., Watertown, Massachusetts 02472
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Dimitri M. Kullmann
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Matthew C. Walker
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Stephanie Schorge
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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The Journal of Neuroscience: 39 (16)
Journal of Neuroscience
Vol. 39, Issue 16
17 Apr 2019
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Epilepsy Gene Therapy Using an Engineered Potassium Channel
Albert Snowball, Elodie Chabrol, Robert C. Wykes, Tawfeeq Shekh-Ahmad, Jonathan H. Cornford, Andreas Lieb, Michael P. Hughes, Giulia Massaro, Ahad A. Rahim, Kevan S. Hashemi, Dimitri M. Kullmann, Matthew C. Walker, Stephanie Schorge
Journal of Neuroscience 17 April 2019, 39 (16) 3159-3169; DOI: 10.1523/JNEUROSCI.1143-18.2019

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Epilepsy Gene Therapy Using an Engineered Potassium Channel
Albert Snowball, Elodie Chabrol, Robert C. Wykes, Tawfeeq Shekh-Ahmad, Jonathan H. Cornford, Andreas Lieb, Michael P. Hughes, Giulia Massaro, Ahad A. Rahim, Kevan S. Hashemi, Dimitri M. Kullmann, Matthew C. Walker, Stephanie Schorge
Journal of Neuroscience 17 April 2019, 39 (16) 3159-3169; DOI: 10.1523/JNEUROSCI.1143-18.2019
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Keywords

  • EEG
  • epilepsy
  • gene therapy
  • lentivirus
  • potassium channel
  • seizure detection

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