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Cover ArticleResearch Articles, Behavioral/Cognitive

Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults

Jaime J. Castrellon, Kendra L. Seaman, Jennifer L. Crawford, Jacob S. Young, Christopher T. Smith, Linh C. Dang, Ming Hsu, Ronald L. Cowan, David H. Zald and Gregory R. Samanez-Larkin
Journal of Neuroscience 9 January 2019, 39 (2) 321-332; DOI: https://doi.org/10.1523/JNEUROSCI.1984-18.2018
Jaime J. Castrellon
1Department of Psychology and Neuroscience,
2Center for Cognitive Neuroscience,
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  • ORCID record for Jaime J. Castrellon
Kendra L. Seaman
2Center for Cognitive Neuroscience,
3Center for the Study of Aging and Human Development, Duke University, Durham, North Carolina 27708,
4Department of Psychology, Yale University, New Haven, Connecticut 06511,
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  • ORCID record for Kendra L. Seaman
Jennifer L. Crawford
4Department of Psychology, Yale University, New Haven, Connecticut 06511,
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Jacob S. Young
5Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240,
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Christopher T. Smith
5Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240,
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Linh C. Dang
5Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240,
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Ming Hsu
6Haas School of Business, University of California Berkeley, Berkeley, California 94720,
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Ronald L. Cowan
5Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240,
7Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, and Nashville, Tennessee 37212,
8Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232
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David H. Zald
5Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240,
7Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, and Nashville, Tennessee 37212,
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Gregory R. Samanez-Larkin
1Department of Psychology and Neuroscience,
2Center for Cognitive Neuroscience,
3Center for the Study of Aging and Human Development, Duke University, Durham, North Carolina 27708,
4Department of Psychology, Yale University, New Haven, Connecticut 06511,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1984-18.2018
PubMed 
30446530
Published By 
Society for Neuroscience
History 
  • Received June 30, 2018
  • Revision received September 20, 2018
  • Accepted November 4, 2018
  • First published November 16, 2018.
  • Version of record published January 9, 2019.
Copyright & Usage 
Copyright © 2019 Castrellon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jaime J. Castrellon1,2,
  2. Kendra L. Seaman2,3,4,
  3. Jennifer L. Crawford4,
  4. Jacob S. Young5,
  5. Christopher T. Smith5,
  6. Linh C. Dang5,
  7. Ming Hsu6,
  8. Ronald L. Cowan5,7,8,
  9. David H. Zald5,7, and
  10. Gregory R. Samanez-Larkin1,2,3,4
  1. 1Department of Psychology and Neuroscience,
  2. 2Center for Cognitive Neuroscience,
  3. 3Center for the Study of Aging and Human Development, Duke University, Durham, North Carolina 27708,
  4. 4Department of Psychology, Yale University, New Haven, Connecticut 06511,
  5. 5Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240,
  6. 6Haas School of Business, University of California Berkeley, Berkeley, California 94720,
  7. 7Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, and Nashville, Tennessee 37212,
  8. 8Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232
  • J.L. Crawford's present address: Department of Psychological and Brain Sciences, Washington University, St. Louis, MO.

  • J.S. Young's present address: Department of Neurological Surgery, University of California, San Francisco, CA.

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Author contributions

  1. Author contributions: J.J.C. wrote the first draft of the paper; J.J.C., K.L.S., D.H.Z., and G.R.S.-L. edited the paper; J.J.C., M.H., D.H.Z., and G.R.S.-L. designed research; J.J.C., J.L.C., J.S.Y., C.T.S., L.C.D., and R.L.C. performed research; J.J.C. and K.L.S. analyzed data; J.J.C., K.L.S., and G.R.S.-L. wrote the paper.

  • J.L. Crawford's present address: Department of Psychological and Brain Sciences, Washington University, St. Louis, MO.

  • J.S. Young's present address: Department of Neurological Surgery, University of California, San Francisco, CA.

Disclosures

    • Received June 30, 2018.
    • Revision received September 20, 2018.
    • Accepted November 4, 2018.
  • This work was supported by National Institute on Aging Pathway to Independence Award R00-AG042596, National Institute on Aging Grant R01-AG044838, and National Institute on Drug Abuse Grant R21-DA033611. Some of the results reported in this manuscript were presented in a poster at the Society for Neuroeconomics (2017). We thank Kevin S. LaBar for comments on portions of the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jaime J. Castrellon, Center for Cognitive Neuroscience, Duke University, Box 90999, Durham, NC 27708. jaime.castrellon{at}duke.edu

Other Version

  • previous version (November 16, 2018).
  • You are viewing the most recent version of this article.

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Article usage: November 2018 to November 2023

AbstractFullPdf
Nov 201812280177
Dec 2018292077
Total 201815200254
Jan 20198232926300
Feb 201918747446
Mar 201914420659
Apr 201911012645
May 20198717034
Jun 20194611117
Jul 20197811448
Aug 20195217432
Oct 20198838538
Nov 20196221250
Dec 20194015535
Total 201917175053704
Jan 20204112233
Feb 20203411227
Mar 2020348831
May 2020317834
Jun 20202512838
Jul 20201610112
Aug 2020148133
Sep 2020275627
Oct 2020255932
Nov 20202211737
Dec 2020116836
Total 20202801010340
Jan 20212411037
Feb 2021319122
Mar 2021355038
Apr 2021325929
May 2021208025
Jun 2021185323
Jul 2021103030
Aug 2021164027
Sep 2021183820
Oct 2021207547
Nov 2021145742
Dec 2021134535
Total 2021251728375
Jan 2022157334
Feb 2022205040
Mar 202265031
Apr 2022287815
May 20221210222
Jun 202269120
Jul 2022186725
Aug 202256014
Sep 20222711540
Oct 20221611625
Nov 20222302
Dec 20223186
Total 2022158850274
Jan 2023126443
Feb 2023104921
Mar 202319409
Apr 2023245719
May 2023153922
Jun 2023193910
Jul 2023108919
Aug 2023105219
Sep 2023207115
Oct 20231410819
Nov 20233111120
Total 2023184719216
Total411083602163
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The Journal of Neuroscience: 39 (2)
Journal of Neuroscience
Vol. 39, Issue 2
9 Jan 2019
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Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults
Jaime J. Castrellon, Kendra L. Seaman, Jennifer L. Crawford, Jacob S. Young, Christopher T. Smith, Linh C. Dang, Ming Hsu, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
Journal of Neuroscience 9 January 2019, 39 (2) 321-332; DOI: 10.1523/JNEUROSCI.1984-18.2018

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Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults
Jaime J. Castrellon, Kendra L. Seaman, Jennifer L. Crawford, Jacob S. Young, Christopher T. Smith, Linh C. Dang, Ming Hsu, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
Journal of Neuroscience 9 January 2019, 39 (2) 321-332; DOI: 10.1523/JNEUROSCI.1984-18.2018
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Keywords

  • decision making
  • delay discounting
  • dopamine
  • effort
  • PET
  • probability

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