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Research Articles, Cellular/Molecular

TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment

Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amélie Fréal, Roderick P. Tas, Willine J. van de Wetering, Karina Timmer, Jasmijn Motshagen, Sam F.B. van Beuningen, Lukas C. Kapitein, Willie J.C. Geerts, Jan A. Post and Casper C. Hoogenraad
Journal of Neuroscience 19 June 2019, 39 (25) 4864-4873; https://doi.org/10.1523/JNEUROSCI.3105-18.2019
Martin Harterink
1Cell Biology, Department of Biology, Faculty of Science, and
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Karin Vocking
1Cell Biology, Department of Biology, Faculty of Science, and
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Xingxiu Pan
1Cell Biology, Department of Biology, Faculty of Science, and
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Eva M. Soriano Jerez
1Cell Biology, Department of Biology, Faculty of Science, and
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Lotte Slenders
1Cell Biology, Department of Biology, Faculty of Science, and
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Amélie Fréal
1Cell Biology, Department of Biology, Faculty of Science, and
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Roderick P. Tas
1Cell Biology, Department of Biology, Faculty of Science, and
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Willine J. van de Wetering
1Cell Biology, Department of Biology, Faculty of Science, and
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Karina Timmer
1Cell Biology, Department of Biology, Faculty of Science, and
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Jasmijn Motshagen
1Cell Biology, Department of Biology, Faculty of Science, and
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Sam F.B. van Beuningen
1Cell Biology, Department of Biology, Faculty of Science, and
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Lukas C. Kapitein
1Cell Biology, Department of Biology, Faculty of Science, and
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Willie J.C. Geerts
2Cryo-Electron Microscopy, Department of Chemistry, Faculty of Science, Utrecht University, 3584 Utrecht, the Netherlands
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Jan A. Post
1Cell Biology, Department of Biology, Faculty of Science, and
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Casper C. Hoogenraad
1Cell Biology, Department of Biology, Faculty of Science, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3105-18.2019
PubMed 
30967428
Published By 
Society for Neuroscience
History 
  • Received December 11, 2018
  • Revision received March 18, 2019
  • Accepted March 18, 2019
  • First published April 9, 2019.
  • Version of record published June 19, 2019.
Copyright & Usage 
Copyright © 2019 the authors

Author Information

  1. Martin Harterink1,
  2. Karin Vocking1,
  3. Xingxiu Pan1,
  4. Eva M. Soriano Jerez1,
  5. Lotte Slenders1,
  6. Amélie Fréal1,
  7. Roderick P. Tas1,
  8. Willine J. van de Wetering1,
  9. Karina Timmer1,
  10. Jasmijn Motshagen1,
  11. Sam F.B. van Beuningen1,
  12. Lukas C. Kapitein1,
  13. Willie J.C. Geerts2,
  14. Jan A. Post1, and
  15. Casper C. Hoogenraad1
  1. 1Cell Biology, Department of Biology, Faculty of Science, and
  2. 2Cryo-Electron Microscopy, Department of Chemistry, Faculty of Science, Utrecht University, 3584 Utrecht, the Netherlands
View Full Text

Author contributions

  1. Author contributions: M.H., K.V., L.C.K., J.A.P., and C.C.H. designed research; M.H., K.V., X.P., E.M.S.J., A.F., R.P.T., W.J.v.d.W., K.T., J.M., and S.F.B.v.B. performed research; M.H., X.P., L.S., and W.J.C.G. analyzed data; L.S. contributed unpublished reagents/analytic tools; M.H. wrote the paper.

Disclosures

    • Received December 11, 2018.
    • Revision received March 18, 2019.
    • Accepted March 18, 2019.
  • This work was supported by the Netherlands Organization for Scientific Research (NWO) (NWO-ALW-TOP to M.H., NWO-ALW-VIDI to L.C.K., NWO-ALW-VICI to C.C.H.) and by the European Research Council (ERC Starting Grant to L.C.K., ERC Consolidator Grant to C.C.H.). We thank Eugene Katrukha for guidance with MATLAB, Elly van Donselaar and Rob Mesman for valuable advice, Purvi Jain, Hans Meeldijk, and Chris Schneijdenberg for technical assistance, and the neuron culture team for the cultures.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jan A. Post at j.a.post{at}uu.nl or Casper C. Hoogenraad at c.hoogenraad{at}uu.nl.

Other Version

  • previous version (April 09, 2019).
  • You are viewing the most recent version of this article.

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AbstractFullPdf
Apr 201923290161
May 2019244046
Jun 2019122910194
Jul 20193533723
Aug 20191072410
Oct 2019913014
Nov 2019923922
Dec 2019532316
Total 20194498254386
Jan 2020225821
Feb 2020154514
Mar 2020134011
May 2020175928
Jun 202095130
Jul 2020105122
Aug 202094126
Sep 2020177932
Oct 2020105626
Nov 2020276038
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Total 2020159594279
Jan 2021105017
Feb 2021142622
Mar 2021126028
Apr 2021164736
May 202145514
Jun 202178428
Jul 202173720
Aug 2021135316
Sep 2021113824
Oct 2021166546
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Dec 2021199448
Total 2021143663351
Jan 2022134237
Feb 2022134024
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Apr 2022125427
May 202295922
Jun 202295730
Jul 202273111
Aug 2022102415
Sep 202273833
Oct 2022245938
Nov 202211411
Dec 20220149
Total 2022118479286
Jan 202383618
Feb 202344017
Mar 2023175927
Apr 202353916
May 2023113424
Jun 202354831
Jul 202363024
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Total 202398536269
Jan 202475123
Feb 202435329
Mar 2024106228
Apr 202474628
May 2024114630
Jun 202484722
Jul 202434120
Aug 202475630
Sep 202472319
Oct 2024133018
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Total 202492533289
Jan 202543433
Feb 202585421
Mar 2025104736
Apr 2025112821
May 2025175027
Jun 202573320
Jul 2025420
Total 202561248158
Total516933072018
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The Journal of Neuroscience: 39 (25)
Journal of Neuroscience
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19 Jun 2019
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TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment
Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amélie Fréal, Roderick P. Tas, Willine J. van de Wetering, Karina Timmer, Jasmijn Motshagen, Sam F.B. van Beuningen, Lukas C. Kapitein, Willie J.C. Geerts, Jan A. Post, Casper C. Hoogenraad
Journal of Neuroscience 19 June 2019, 39 (25) 4864-4873; DOI: 10.1523/JNEUROSCI.3105-18.2019

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TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment
Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amélie Fréal, Roderick P. Tas, Willine J. van de Wetering, Karina Timmer, Jasmijn Motshagen, Sam F.B. van Beuningen, Lukas C. Kapitein, Willie J.C. Geerts, Jan A. Post, Casper C. Hoogenraad
Journal of Neuroscience 19 June 2019, 39 (25) 4864-4873; DOI: 10.1523/JNEUROSCI.3105-18.2019
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Keywords

  • axon initial segment (AIS)
  • correlative light and electron microscopy (CLEM)
  • microtubule
  • TRIM46

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