Article Information
- Received November 29, 2018
- Revision received March 31, 2019
- Accepted April 16, 2019
- First published April 23, 2019.
- Version of record published June 26, 2019.
Author Information
- Vamshidhar R. Vangoor1,
- Cristina R. Reschke2,3,*,
- Ketharini Senthilkumar1,*,
- Lieke L. van de Haar1,
- Marina de Wit1,
- Giuliano Giuliani1,
- Mark H. Broekhoven1,
- Gareth Morris2,3,4,
- Tobias Engel2,
- Gary P. Brennan2,3,
- Ronan M. Conroy5,
- Peter C. van Rijen6,
- Peter H. Gosselaar6,
- Stephanie Schorge4,
- Roel Q.J. Schaapveld7,
- David C. Henshall2,3,
- Pierre N.E. De Graan1, and
- R. Jeroen Pasterkamp1
- 1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
- 2Department of Physiology and Medical Physics,
- 3FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland,
- 4Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
- 5Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland,
- 6Department of Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands, and
- 7InteRNA Technologies 3584 CM Utrecht, The Netherlands
Author contributions
Author contributions: V.R.V., C.R.R., K.S., L.L.v.d.H., G.G., G.M., D.C.H., P.N.E.D.G., and R.J.P. designed research; V.R.V., C.R.R., K.S., L.L.v.d.H., M.d.W., G.G., M.H.B., G.M., T.E., and G.P.B. performed research; V.R.V., C.R.R., K.S., L.L.v.d.H., M.d.W., G.G., M.H.B., G.M., G.P.B., R.M.C., and R.J.P. analyzed data; V.R.V. and R.J.P. wrote the paper; P.C.v.R., P.H.G., S.S., and R.Q.J.S. contributed unpublished reagents/analytic tools.
↵*C.R.R. and K.S. contributed equally to this work.
Disclosures
- Received November 29, 2018.
- Revision received March 31, 2019.
- Accepted April 16, 2019.
This work was supported by European Union's 7th Framework Programme Grant Agreement 602130, EpimiRNA, and Dutch Epilepsiefonds (WAR 12-08, 15-05), and Netherlands Organization for Scientific Research to R.J.P. We thank Prof. Jorgen Kjems for providing the pJEBB vector backbone; and Prof. Gerhard Schratt for the Mef2-vp16 vector.
R.Q.J.S. is a shareholder in InteRNA Technologies B.V. R.Q.J.S. is a stock option holder in InteRNA Technologies B.V. The remaining authors declare no competing financial interests.
- Correspondence should be addressed to R. Jeroen Pasterkamp at r.j.pasterkamp{at}umcutrecht.nl.
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