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Research Articles, Cellular/Molecular

Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures

Vamshidhar R. Vangoor, Cristina R. Reschke, Ketharini Senthilkumar, Lieke L. van de Haar, Marina de Wit, Giuliano Giuliani, Mark H. Broekhoven, Gareth Morris, Tobias Engel, Gary P. Brennan, Ronan M. Conroy, Peter C. van Rijen, Peter H. Gosselaar, Stephanie Schorge, Roel Q.J. Schaapveld, David C. Henshall, Pierre N.E. De Graan and R. Jeroen Pasterkamp
Journal of Neuroscience 26 June 2019, 39 (26) 5064-5079; DOI: https://doi.org/10.1523/JNEUROSCI.3014-18.2019
Vamshidhar R. Vangoor
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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  • ORCID record for Vamshidhar R. Vangoor
Cristina R. Reschke
2Department of Physiology and Medical Physics,
3FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland,
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Ketharini Senthilkumar
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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Lieke L. van de Haar
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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  • ORCID record for Lieke L. van de Haar
Marina de Wit
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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Giuliano Giuliani
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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Mark H. Broekhoven
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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Gareth Morris
2Department of Physiology and Medical Physics,
3FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland,
4Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Tobias Engel
2Department of Physiology and Medical Physics,
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Gary P. Brennan
2Department of Physiology and Medical Physics,
3FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland,
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Ronan M. Conroy
5Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland,
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Peter C. van Rijen
6Department of Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands, and
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Peter H. Gosselaar
6Department of Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands, and
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Stephanie Schorge
4Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
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Roel Q.J. Schaapveld
7InteRNA Technologies 3584 CM Utrecht, The Netherlands
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David C. Henshall
2Department of Physiology and Medical Physics,
3FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland,
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Pierre N.E. De Graan
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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R. Jeroen Pasterkamp
1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3014-18.2019
PubMed 
31015341
Published By 
Society for Neuroscience
History 
  • Received November 29, 2018
  • Revision received March 31, 2019
  • Accepted April 16, 2019
  • First published April 23, 2019.
  • Version of record published June 26, 2019.
Copyright & Usage 
Copyright © 2019 the authors

Author Information

  1. Vamshidhar R. Vangoor1,
  2. Cristina R. Reschke2,3,*,
  3. Ketharini Senthilkumar1,*,
  4. Lieke L. van de Haar1,
  5. Marina de Wit1,
  6. Giuliano Giuliani1,
  7. Mark H. Broekhoven1,
  8. Gareth Morris2,3,4,
  9. Tobias Engel2,
  10. Gary P. Brennan2,3,
  11. Ronan M. Conroy5,
  12. Peter C. van Rijen6,
  13. Peter H. Gosselaar6,
  14. Stephanie Schorge4,
  15. Roel Q.J. Schaapveld7,
  16. David C. Henshall2,3,
  17. Pierre N.E. De Graan1, and
  18. R. Jeroen Pasterkamp1
  1. 1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands,
  2. 2Department of Physiology and Medical Physics,
  3. 3FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin D02, Ireland,
  4. 4Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom,
  5. 5Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland,
  6. 6Department of Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands, and
  7. 7InteRNA Technologies 3584 CM Utrecht, The Netherlands
View Full Text

Author contributions

  1. Author contributions: V.R.V., C.R.R., K.S., L.L.v.d.H., G.G., G.M., D.C.H., P.N.E.D.G., and R.J.P. designed research; V.R.V., C.R.R., K.S., L.L.v.d.H., M.d.W., G.G., M.H.B., G.M., T.E., and G.P.B. performed research; V.R.V., C.R.R., K.S., L.L.v.d.H., M.d.W., G.G., M.H.B., G.M., G.P.B., R.M.C., and R.J.P. analyzed data; V.R.V. and R.J.P. wrote the paper; P.C.v.R., P.H.G., S.S., and R.Q.J.S. contributed unpublished reagents/analytic tools.

  2. ↵*C.R.R. and K.S. contributed equally to this work.

Disclosures

    • Received November 29, 2018.
    • Revision received March 31, 2019.
    • Accepted April 16, 2019.
  • This work was supported by European Union's 7th Framework Programme Grant Agreement 602130, EpimiRNA, and Dutch Epilepsiefonds (WAR 12-08, 15-05), and Netherlands Organization for Scientific Research to R.J.P. We thank Prof. Jorgen Kjems for providing the pJEBB vector backbone; and Prof. Gerhard Schratt for the Mef2-vp16 vector.

  • R.Q.J.S. is a shareholder in InteRNA Technologies B.V. R.Q.J.S. is a stock option holder in InteRNA Technologies B.V. The remaining authors declare no competing financial interests.

  • Correspondence should be addressed to R. Jeroen Pasterkamp at r.j.pasterkamp{at}umcutrecht.nl.

Other Version

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Apr 20191337050
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Mar 20202119828
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May 202228332
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Jul 202235219
Aug 2022129917
Sep 2022814923
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Total 20221041390323
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Mar 20231215412
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Jun 20232111212
Jul 202365012
Aug 202343617
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Total 202384848146
Total565293181399
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The Journal of Neuroscience: 39 (26)
Journal of Neuroscience
Vol. 39, Issue 26
26 Jun 2019
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Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures
Vamshidhar R. Vangoor, Cristina R. Reschke, Ketharini Senthilkumar, Lieke L. van de Haar, Marina de Wit, Giuliano Giuliani, Mark H. Broekhoven, Gareth Morris, Tobias Engel, Gary P. Brennan, Ronan M. Conroy, Peter C. van Rijen, Peter H. Gosselaar, Stephanie Schorge, Roel Q.J. Schaapveld, David C. Henshall, Pierre N.E. De Graan, R. Jeroen Pasterkamp
Journal of Neuroscience 26 June 2019, 39 (26) 5064-5079; DOI: 10.1523/JNEUROSCI.3014-18.2019

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Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures
Vamshidhar R. Vangoor, Cristina R. Reschke, Ketharini Senthilkumar, Lieke L. van de Haar, Marina de Wit, Giuliano Giuliani, Mark H. Broekhoven, Gareth Morris, Tobias Engel, Gary P. Brennan, Ronan M. Conroy, Peter C. van Rijen, Peter H. Gosselaar, Stephanie Schorge, Roel Q.J. Schaapveld, David C. Henshall, Pierre N.E. De Graan, R. Jeroen Pasterkamp
Journal of Neuroscience 26 June 2019, 39 (26) 5064-5079; DOI: 10.1523/JNEUROSCI.3014-18.2019
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Keywords

  • antagomirs
  • epilepsy
  • MEF2
  • mesial temporal lobe epilepsy
  • miRNA
  • RNA sequencing

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