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Research Articles, Development/Plasticity/Repair

Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins

Christopher R. Bye, Valeria Rytova, Walaa F. Alsanie, Clare L. Parish and Lachlan H. Thompson
Journal of Neuroscience 21 August 2019, 39 (34) 6656-6667; https://doi.org/10.1523/JNEUROSCI.0278-19.2019
Christopher R. Bye
Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Royal Parade, Parkville, Victoria, Australia 3010
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Valeria Rytova
Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Royal Parade, Parkville, Victoria, Australia 3010
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Walaa F. Alsanie
Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Royal Parade, Parkville, Victoria, Australia 3010
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Clare L. Parish
Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Royal Parade, Parkville, Victoria, Australia 3010
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Lachlan H. Thompson
Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Royal Parade, Parkville, Victoria, Australia 3010
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0278-19.2019
PubMed 
31300520
Published By 
Society for Neuroscience
History 
  • Received February 5, 2019
  • Revision received May 21, 2019
  • Accepted July 3, 2019
  • First published July 12, 2019.
  • Version of record published August 21, 2019.
Copyright & Usage 
Copyright © 2019 the authors

Author Information

  1. Christopher R. Bye,
  2. Valeria Rytova,
  3. Walaa F. Alsanie,
  4. Clare L. Parish*, and
  5. Lachlan H. Thompson*
  1. Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Royal Parade, Parkville, Victoria, Australia 3010
  • W. F. Alsanie's present address: Department of Clinical Laboratories, The Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.

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Author contributions

  1. Author contributions: C.R.B., C.L.P., and L.H.T. designed research; C.R.B., V.R., and W.F.A. performed research; C.R.B., W.F.A., C.L.P., and L.H.T. analyzed data; C.R.B., C.L.P., and L.H.T. wrote the paper; C.L.P. and L.H.T. edited the paper.

  2. ↵*C.L.P. and L.H.T. contributed equally to this work.

  • W. F. Alsanie's present address: Department of Clinical Laboratories, The Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.

Disclosures

    • Received February 5, 2019.
    • Revision received May 21, 2019.
    • Accepted July 3, 2019.
  • This work was supported by the National Health and Medical Research Council (NHMRC Grants 1042584 and 1022637). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from an Operational Infrastructure Support Grant. C.R.B. is supported by an NHMRC Peter Doherty training fellowship, C.L.P. is an NHMRC Senior Research Fellow. We thank Jason Howitt for technical assistance with PLA Assays, Mong Tien and Jessica Kauhausen for assistance with tissue processing and histology, and Richard Anderson and John Hemperly for provision of the 6096 L1 blocking antibody.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Christopher R. Bye at chris.bye{at}florey.edu.au or Lachlan H. Thompson at lachlant{at}unimelb.edu.au

Other Version

  • previous version (July 12, 2019).
  • You are viewing the most recent version of this article.

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Article usage: July 2019 to November 2025

AbstractFullPdf
Jul 2019745075
Aug 201917748286
Oct 20192092716
Nov 20191081711
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Total 20192917141199
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Apr 20226405
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Total 202287415246
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Jul 2023153218
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Total 202390835260
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Jul 202423023
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Apr 202522913
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Jul 202594425
Aug 2025124322
Sep 202511499
Oct 202595719
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Total 202590459170
Total363932741624
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The Journal of Neuroscience: 39 (34)
Journal of Neuroscience
Vol. 39, Issue 34
21 Aug 2019
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Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins
Christopher R. Bye, Valeria Rytova, Walaa F. Alsanie, Clare L. Parish, Lachlan H. Thompson
Journal of Neuroscience 21 August 2019, 39 (34) 6656-6667; DOI: 10.1523/JNEUROSCI.0278-19.2019

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Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins
Christopher R. Bye, Valeria Rytova, Walaa F. Alsanie, Clare L. Parish, Lachlan H. Thompson
Journal of Neuroscience 21 August 2019, 39 (34) 6656-6667; DOI: 10.1523/JNEUROSCI.0278-19.2019
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Keywords

  • CAMs
  • connectivity
  • guidance
  • mesencephalon
  • Nrp1

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