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Research Articles, Neurobiology of Disease

Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance

L. Passamonti, K.A. Tsvetanov, P.S. Jones, W.R. Bevan-Jones, R. Arnold, R.J. Borchert, E. Mak, L. Su, J.T. O'Brien and J.B. Rowe
Journal of Neuroscience 4 September 2019, 39 (36) 7218-7226; DOI: https://doi.org/10.1523/JNEUROSCI.2574-18.2019
L. Passamonti
1Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Consiglio Nazionale delle Ricerche (CNR), 20090, Milano, Italy,
2Departments of Clinical Neurosciences,
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K.A. Tsvetanov
2Departments of Clinical Neurosciences,
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P.S. Jones
2Departments of Clinical Neurosciences,
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W.R. Bevan-Jones
3Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and
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R. Arnold
2Departments of Clinical Neurosciences,
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R.J. Borchert
2Departments of Clinical Neurosciences,
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E. Mak
3Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and
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L. Su
3Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and
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J.T. O'Brien
3Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and
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J.B. Rowe
2Departments of Clinical Neurosciences,
4Cognition and Brain Sciences Unit, Medical Research Council, Cambridge CB2 7EF, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2574-18.2019
PubMed 
31320450
Published By 
Society for Neuroscience
History 
  • Received October 5, 2018
  • Revision received March 25, 2019
  • Accepted April 11, 2019
  • First published July 18, 2019.
  • Version of record published September 4, 2019.
Copyright & Usage 
Copyright © 2019 Passamonti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. L. Passamonti1,2,*,
  2. K.A. Tsvetanov2,*,
  3. P.S. Jones2,
  4. W.R. Bevan-Jones3,
  5. R. Arnold2,
  6. R.J. Borchert2,
  7. E. Mak3,
  8. L. Su3,
  9. J.T. O'Brien3,†, and
  10. J.B. Rowe2,4,†
  1. 1Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Consiglio Nazionale delle Ricerche (CNR), 20090, Milano, Italy,
  2. 2Departments of Clinical Neurosciences,
  3. 3Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and
  4. 4Cognition and Brain Sciences Unit, Medical Research Council, Cambridge CB2 7EF, United Kingdom
View Full Text

Author contributions

  1. Author contributions: L.P., K.A.T., J.T.O., and J.B.R. designed research; L.P., W.R.B.-J., and R.A. performed research; L.P., K.A.T., P.S.J., and R.J.B. analyzed data; L.P., K.A.T., P.S.J., J.B.R., R.A., R.J.B., E.M., L.S., J.T.O., wrote the paper.

Disclosures

    • Received October 5, 2018.
    • Revision received March 25, 2019.
    • Accepted April 11, 2019.
  • ↵*L.P. and K.A.T. are co-first authors.

  • ↵†J.T.O. and J.B.R. are co-last authors.

  • This work was supported by the National Institute for Health Research Cambridge Biomedical Research Centre and Biomedical Research Unit in Dementia (NIHR; RG64473), the Wellcome Trust (103838 to J.B.R.), the Medical Research Council (RG91365/SUAG/004 and MR/P01271X/1), Alzheimer's Research UK to L.S (ARUK-SRF2017B-1), and by a British Academy Postdoctoral Fellowship to K.A.T. (PF160048). We thank our volunteers and the radiographers/technologists at WBIC and PET/CT, Addenbrooke's Hospital, for their invaluable support in data acquisition; the NIHR Eastern Dementias and Neurodegenerative Diseases Research Network for help with subject recruitment; and Dr Istvan Boros and others at Wolfson Brain Imaging Centre RPU for the manufacture of [11C]PK11195 and [11C]PiB.

  • J.T.O. has served as deputy editor of International Psychogeriatrics, received Grant support from Avid (Lilly), and served as a consultant for Avid and GE Healthcare, all for matters not related to the current study. J.B.R. serves as editor to Brain, has been a consultant for Asceneuron and Syncona, and has received academic Grant funding from AZ-MedImmune, Janssen, and Lilly, unrelated to this study. The remaining authors declare no competing financial interests.

  • Correspondence should be addressed to L. Passamonti at lp337{at}medschl.cam.ac.uk

Other Version

  • previous version (July 18, 2019).
  • You are viewing the most recent version of this article.

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Article usage: July 2019 to September 2023

AbstractFullPdf
Jul 20197590155
Aug 2019288064
Oct 2019217528152
Nov 201911726186
Dec 20195414757
Total 20191435936514
Jan 20206618967
Feb 20208417989
Mar 20206211466
May 20207013779
Jun 20204110172
Jul 202038132134
Aug 202029128128
Sep 202073163311
Oct 202051160256
Nov 202049117339
Dec 20208913996
Total 202065215591637
Jan 20213810753
Feb 20217915694
Mar 20215051098
Apr 20213323650
May 2021259061
Jun 2021258741
Jul 2021246848
Aug 2021188360
Sep 20214911573
Oct 2021437884
Nov 2021337056
Dec 2021336747
Total 20214501667765
Jan 2022396438
Feb 2022315930
Mar 2022306749
Apr 2022647836
May 2022408050
Jun 2022275947
Jul 2022263921
Aug 2022175626
Sep 2022476537
Oct 2022387342
Nov 202212117
Dec 202272417
Total 2022378675400
Jan 2023264747
Feb 2023336027
Mar 2023298752
Apr 2023596550
May 2023305545
Jun 2023295141
Jul 2023307846
Aug 2023236828
Sep 2023219428
Total 2023280605364
Total319554423680
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The Journal of Neuroscience: 39 (36)
Journal of Neuroscience
Vol. 39, Issue 36
4 Sep 2019
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Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance
L. Passamonti, K.A. Tsvetanov, P.S. Jones, W.R. Bevan-Jones, R. Arnold, R.J. Borchert, E. Mak, L. Su, J.T. O'Brien, J.B. Rowe
Journal of Neuroscience 4 September 2019, 39 (36) 7218-7226; DOI: 10.1523/JNEUROSCI.2574-18.2019

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Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance
L. Passamonti, K.A. Tsvetanov, P.S. Jones, W.R. Bevan-Jones, R. Arnold, R.J. Borchert, E. Mak, L. Su, J.T. O'Brien, J.B. Rowe
Journal of Neuroscience 4 September 2019, 39 (36) 7218-7226; DOI: 10.1523/JNEUROSCI.2574-18.2019
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Keywords

  • [11C]PK11195
  • Alzheimer's disease
  • functional connectivity
  • independent component analysis
  • neuroinflammation
  • PET

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