Article Information
- Received October 5, 2018
- Revision received March 25, 2019
- Accepted April 11, 2019
- First published July 18, 2019.
- Version of record published September 4, 2019.
Author Information
- L. Passamonti1,2,*,
- K.A. Tsvetanov2,*,
- P.S. Jones2,
- W.R. Bevan-Jones3,
- R. Arnold2,
- R.J. Borchert2,
- E. Mak3,
- L. Su3,
- J.T. O'Brien3,†, and
- J.B. Rowe2,4,†
- 1Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Consiglio Nazionale delle Ricerche (CNR), 20090, Milano, Italy,
- 2Departments of Clinical Neurosciences,
- 3Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom, and
- 4Cognition and Brain Sciences Unit, Medical Research Council, Cambridge CB2 7EF, United Kingdom
Author contributions
Author contributions: L.P., K.A.T., J.T.O., and J.B.R. designed research; L.P., W.R.B.-J., and R.A. performed research; L.P., K.A.T., P.S.J., and R.J.B. analyzed data; L.P., K.A.T., P.S.J., J.B.R., R.A., R.J.B., E.M., L.S., J.T.O., wrote the paper.
Disclosures
- Received October 5, 2018.
- Revision received March 25, 2019.
- Accepted April 11, 2019.
↵*L.P. and K.A.T. are co-first authors.
↵†J.T.O. and J.B.R. are co-last authors.
This work was supported by the National Institute for Health Research Cambridge Biomedical Research Centre and Biomedical Research Unit in Dementia (NIHR; RG64473), the Wellcome Trust (103838 to J.B.R.), the Medical Research Council (RG91365/SUAG/004 and MR/P01271X/1), Alzheimer's Research UK to L.S (ARUK-SRF2017B-1), and by a British Academy Postdoctoral Fellowship to K.A.T. (PF160048). We thank our volunteers and the radiographers/technologists at WBIC and PET/CT, Addenbrooke's Hospital, for their invaluable support in data acquisition; the NIHR Eastern Dementias and Neurodegenerative Diseases Research Network for help with subject recruitment; and Dr Istvan Boros and others at Wolfson Brain Imaging Centre RPU for the manufacture of [11C]PK11195 and [11C]PiB.
J.T.O. has served as deputy editor of International Psychogeriatrics, received Grant support from Avid (Lilly), and served as a consultant for Avid and GE Healthcare, all for matters not related to the current study. J.B.R. serves as editor to Brain, has been a consultant for Asceneuron and Syncona, and has received academic Grant funding from AZ-MedImmune, Janssen, and Lilly, unrelated to this study. The remaining authors declare no competing financial interests.
- Correspondence should be addressed to L. Passamonti at lp337{at}medschl.cam.ac.uk
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