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Research Articles, Behavioral/Cognitive

A Posterior–Anterior Distinction between Scene Perception and Scene Construction in Human Medial Parietal Cortex

Edward H. Silson, Adrian W. Gilmore, Sarah E. Kalinowski, Adam Steel, Alexis Kidder, Alex Martin and Chris I. Baker
Journal of Neuroscience 23 January 2019, 39 (4) 705-717; DOI: https://doi.org/10.1523/JNEUROSCI.1219-18.2018
Edward H. Silson
1Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
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Adrian W. Gilmore
1Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
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Sarah E. Kalinowski
1Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
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Adam Steel
1Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, United Kingdom
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Alexis Kidder
1Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
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Alex Martin
1Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
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Chris I. Baker
1Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, Maryland 20892-1366, and
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Abstract

Human retrosplenial complex (RSC), located in medial parietal cortex, has been implicated in numerous cognitive functions, including scene perception, spatial navigation, and autobiographical memory retrieval. Recently, a posterior–anterior distinction within RSC was proposed, such that posterior aspects process scene-related visual information (constituting a medial place area [MPA]), whereas anterior aspects process information that is vividly retrieved from memory, thereby supporting remembering and potentially navigation. Here, we tested this proposed distinction in a single group of participants (both male and female) using fMRI with both perceptual and mnemonic tasks. After completing a resting-state scan, participants performed a task that required constructing scenes from memory and completed a scene selectivity localizer task. We tested directly perceptual and mnemonic responses in MPA and an anterior, connectivity-defined region (CON), which showed strong functional connectivity with anterior parahippocampal place area. A double dissociation was observed, such that CON was more strongly activated during scene construction than was MPA, whereas MPA was more perceptually responsive than CON. Further, peak responses from the scene construction task were anterior to perceptual peaks in all but 1 participant and hemisphere. Finally, through analyses of the posterior–anterior response profiles, we identify the fundus of the parieto-occipital sulcus as a potential location for the crossover from perceptual to mnemonic representations and highlight a potential left-hemisphere advantage for mnemonic representations. Collectively, our results support a distinction between posterior and anterior aspects of the RSC, suggesting that more specific functional-anatomic terms should be used in its place in future work.

SIGNIFICANCE STATEMENT The retrosplenial complex (RSC) has been implicated in vision, spatial cognition, and memory. We previously speculated on a potential posterior–anterior distinction within RSC for scene perception and memory-based scene construction/navigation. Here, we tested this distinction through a combination of resting-state, perceptual, and mnemonic task data. Consistent with our predictions, we demonstrate that perceptual responses peak consistently posterior of those elicited by memory-based scene construction within the broader RSC. Further, we highlight (1) the fundus of the parieto-occipital sulcus as a landmark for the transition between these representations, (2) the anterior bank of parieto-occipital sulcus as the point of maximal separation between these representations, and (3) identify a potential hemispheric asymmetry in mnemonic representations. These data support functional dissociations within RSC.

  • fMRI
  • memory
  • RSC
  • scene construction
  • scene perception
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The Journal of Neuroscience: 39 (4)
Journal of Neuroscience
Vol. 39, Issue 4
23 Jan 2019
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A Posterior–Anterior Distinction between Scene Perception and Scene Construction in Human Medial Parietal Cortex
Edward H. Silson, Adrian W. Gilmore, Sarah E. Kalinowski, Adam Steel, Alexis Kidder, Alex Martin, Chris I. Baker
Journal of Neuroscience 23 January 2019, 39 (4) 705-717; DOI: 10.1523/JNEUROSCI.1219-18.2018

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A Posterior–Anterior Distinction between Scene Perception and Scene Construction in Human Medial Parietal Cortex
Edward H. Silson, Adrian W. Gilmore, Sarah E. Kalinowski, Adam Steel, Alexis Kidder, Alex Martin, Chris I. Baker
Journal of Neuroscience 23 January 2019, 39 (4) 705-717; DOI: 10.1523/JNEUROSCI.1219-18.2018
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Keywords

  • fMRI
  • memory
  • RSC
  • scene construction
  • scene perception

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