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Research Articles, Cellular/Molecular

Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits

Omar Alkhatib, Robson da Costa, Clive Gentry, Talisia Quallo, Stefanie Mannebach, Petra Weissgerber, Marc Freichel, Stephan E. Philipp, Stuart Bevan and David A. Andersson
Journal of Neuroscience 2 October 2019, 39 (40) 7840-7852; https://doi.org/10.1523/JNEUROSCI.0882-19.2019
Omar Alkhatib
1Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom
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Robson da Costa
1Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom
2School of Pharmacy, Universidade Federal do Rio de Janeiro, 21941-908 Rio de Janeiro, Brazil
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Clive Gentry
1Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom
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Talisia Quallo
1Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom
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  • ORCID record for Talisia Quallo
Stefanie Mannebach
3Experimental and Clinical Pharmacology and Toxicology/Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany
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Petra Weissgerber
3Experimental and Clinical Pharmacology and Toxicology/Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany
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Marc Freichel
4Pharmacological Institute, Ruprecht-Karls-University Heidelberg, 69120 Heidelberg, Germany, and
5German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, 69120 Heidelberg, Germany
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Stephan E. Philipp
3Experimental and Clinical Pharmacology and Toxicology/Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany
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Stuart Bevan
1Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom
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David A. Andersson
1Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom
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  • ORCID record for David A. Andersson
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The Journal of Neuroscience: 39 (40)
Journal of Neuroscience
Vol. 39, Issue 40
2 Oct 2019
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Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits
Omar Alkhatib, Robson da Costa, Clive Gentry, Talisia Quallo, Stefanie Mannebach, Petra Weissgerber, Marc Freichel, Stephan E. Philipp, Stuart Bevan, David A. Andersson
Journal of Neuroscience 2 October 2019, 39 (40) 7840-7852; DOI: 10.1523/JNEUROSCI.0882-19.2019

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Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits
Omar Alkhatib, Robson da Costa, Clive Gentry, Talisia Quallo, Stefanie Mannebach, Petra Weissgerber, Marc Freichel, Stephan E. Philipp, Stuart Bevan, David A. Andersson
Journal of Neuroscience 2 October 2019, 39 (40) 7840-7852; DOI: 10.1523/JNEUROSCI.0882-19.2019
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Keywords

  • DRG
  • G-protein beta-gamma
  • GPCR
  • ion channels
  • pain
  • TRPM3

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