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Research Articles, Behavioral/Cognitive

Reward Boosts Neural Coding of Task Rules to Optimize Cognitive Flexibility

Sam Hall-McMaster, Paul S. Muhle-Karbe, Nicholas E. Myers and Mark G. Stokes
Journal of Neuroscience 23 October 2019, 39 (43) 8549-8561; DOI: https://doi.org/10.1523/JNEUROSCI.0631-19.2019
Sam Hall-McMaster
1Department of Experimental Psychology, University of Oxford, Oxford OX2 6AE, United Kingdom, and
2Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 9DU, United Kingdom
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Paul S. Muhle-Karbe
1Department of Experimental Psychology, University of Oxford, Oxford OX2 6AE, United Kingdom, and
2Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 9DU, United Kingdom
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Nicholas E. Myers
1Department of Experimental Psychology, University of Oxford, Oxford OX2 6AE, United Kingdom, and
2Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 9DU, United Kingdom
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Mark G. Stokes
1Department of Experimental Psychology, University of Oxford, Oxford OX2 6AE, United Kingdom, and
2Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 9DU, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0631-19.2019
PubMed 
31519820
Published By 
Society for Neuroscience
History 
  • Received March 19, 2019
  • Revision received August 19, 2019
  • Accepted August 22, 2019
  • First published September 13, 2019.
  • Version of record published October 23, 2019.
Copyright & Usage 
Copyright © 2019 McMaster et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sam Hall-McMaster1,2,
  2. Paul S. Muhle-Karbe1,2,
  3. Nicholas E. Myers1,2,*, and
  4. Mark G. Stokes1,2,*
  1. 1Department of Experimental Psychology, University of Oxford, Oxford OX2 6AE, United Kingdom, and
  2. 2Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX3 9DU, United Kingdom
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Author contributions

  1. Author contributions: S.H.-M., P.S.M.-K., N.E.M., and M.G.S. designed research; S.H.-M. performed research; N.E.M. and M.G.S. contributed unpublished reagents/analytic tools; S.H.-M., P.S.M.-K., and N.E.M. analyzed data; S.H.-M., P.S.M.-K., N.E.M., and M.G.S. wrote the paper.

  2. ↵*N.E.M. and M.G.S. made equal contributions to this work.

Disclosures

    • Received March 19, 2019.
    • Revision received August 19, 2019.
    • Accepted August 22, 2019.
  • This research was funded by Biotechnology and Biological Sciences Research Council Grant BB/M010732/1 and James S. McDonnell Foundation Scholar Award 220020405 to M.G.S.; and by the National Institute for Health Research Oxford Health Biomedical Research Centre. S.H.-M. is funded by the Rutherford Foundation and William Georgetti Trusts, through the New Zealand Government. P.S.M.-K. is funded by the Research Foundation Flanders (Grant 12R8817N), the Wellcome Trust (Grant 210849/Z/18/Z), and Linacre College Oxford (EPA Cephalosphorin Junior Research Fellowship). N.E.M. is funded by the Wellcome Trust (Grant 201409Z/16/Z) and University College Oxford. The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (Grant 203139/Z/16/Z). We thank Fabrice Luyckx and Hamed Nili for technical advice, as well as John Grogan and Sanjay Manohar for useful discussion about interpreting the results.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Sam Hall-McMaster at sam.hall-mcmaster{at}psy.ox.ac.uk

Other Version

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The Journal of Neuroscience: 39 (43)
Journal of Neuroscience
Vol. 39, Issue 43
23 Oct 2019
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Reward Boosts Neural Coding of Task Rules to Optimize Cognitive Flexibility
Sam Hall-McMaster, Paul S. Muhle-Karbe, Nicholas E. Myers, Mark G. Stokes
Journal of Neuroscience 23 October 2019, 39 (43) 8549-8561; DOI: 10.1523/JNEUROSCI.0631-19.2019

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Reward Boosts Neural Coding of Task Rules to Optimize Cognitive Flexibility
Sam Hall-McMaster, Paul S. Muhle-Karbe, Nicholas E. Myers, Mark G. Stokes
Journal of Neuroscience 23 October 2019, 39 (43) 8549-8561; DOI: 10.1523/JNEUROSCI.0631-19.2019
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Keywords

  • cognitive control
  • flexibility
  • motivation
  • representational similarity analysis
  • reward prospect

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