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PreviousNext
Cover ArticleResearch Articles, Development/Plasticity/Repair

The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor Axons

Michele E. Frendo, Alexandra da Silva, Keith D. Phan, Soizic Riche and Samantha J. Butler
Journal of Neuroscience 20 November 2019, 39 (47) 9316-9327; DOI: https://doi.org/10.1523/JNEUROSCI.0648-19.2019
Michele E. Frendo
3Neuroscience Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089
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Alexandra da Silva
1Department of Neurobiology,
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Keith D. Phan
1Department of Neurobiology,
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Soizic Riche
1Department of Neurobiology,
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Samantha J. Butler
1Department of Neurobiology,
2Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California 90095, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0648-19.2019
PubMed 
31578231
Published By 
Society for Neuroscience
History 
  • Received March 21, 2019
  • Revision received August 12, 2019
  • Accepted August 29, 2019
  • First published October 2, 2019.
  • Version of record published November 20, 2019.
Copyright & Usage 
Copyright © 2019 the authors

Author Information

  1. Michele E. Frendo3,
  2. Alexandra da Silva1,
  3. Keith D. Phan1,
  4. Soizic Riche1, and
  5. Samantha J. Butler1,2
  1. 1Department of Neurobiology,
  2. 2Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, California 90095, and
  3. 3Neuroscience Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089
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Author contributions

  1. Author contributions: M.E.F., A.d.S., K.D.P., and S.J.B. designed research; M.E.F., A.d.S., K.D.P., S.R., and S.J.B. performed research; M.E.F., A.d.S., K.D.P., S.R., and S.J.B. analyzed data; M.E.F., A.d.S., K.D.P., and S.J.B. edited the paper; S.J.B. wrote the paper.

Disclosures

    • Received March 21, 2019.
    • Revision received August 12, 2019.
    • Accepted August 29, 2019.
  • This work was supported by National Institutes of Health National Research Service Award Fellowship NS 077619 to M.E.F., and Craig H. Neilsen Foundation Grant 284402, Merkin Foundation, and National Institutes of Health Grant NS 063999 to S.J.B. We thank Zhengping Zia for the Limk1 mutant mice line; Bennett Novitch for FoxP1 antibodies; Aaron McGee for teaching us the sciatic crush protocol; David McKemy and his laboratory for help with the sensory behavioral tests; Tanmoy Bhattacharya, Olivia Handley, Harley Kornblum, Francesca Mariani, Aaron McGee, Bennett Novitch, Caroline Pearson, and Larry Zipursky for invaluable discussions; and Reggie Edgerton, Bennett Novitch, and Larry Zipursky for comments on the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Samantha J. Butler at butlersj{at}ucla.edu

Other Version

  • previous version (October 02, 2019).
  • You are viewing the most recent version of this article.

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Article usage: October 2019 to May 2023

AbstractFullPdf
Oct 20191312096
Nov 20191297113115
Dec 20194035625
Total 20193012169236
Jan 20202954025
Feb 20201772010
Mar 20201312111
May 2020752419
Jun 2020186125
Jul 202085923
Aug 202075223
Sep 2020276432
Oct 2020175732
Nov 2020169122
Dec 2020136022
Total 2020784549244
Jan 2021238152
Feb 202184817
Mar 2021126423
Apr 202111548
May 202153415
Jun 20213329
Jul 202144522
Aug 2021134615
Sep 202134618
Oct 202145231
Nov 202135433
Dec 202133912
Total 202192595255
Jan 202266323
Feb 202255816
Mar 202295615
Apr 202255313
May 202295219
Jun 202245510
Jul 202223710
Aug 20223406
Sep 202273820
Oct 2022114015
Nov 20221126
Dec 20221168
Total 202263520161
Jan 202344316
Feb 20235355
Mar 202333717
Apr 202374413
May 20237258
Total 20232618459
Total39772017955
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The Journal of Neuroscience: 39 (47)
Journal of Neuroscience
Vol. 39, Issue 47
20 Nov 2019
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The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor Axons
Michele E. Frendo, Alexandra da Silva, Keith D. Phan, Soizic Riche, Samantha J. Butler
Journal of Neuroscience 20 November 2019, 39 (47) 9316-9327; DOI: 10.1523/JNEUROSCI.0648-19.2019

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The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor Axons
Michele E. Frendo, Alexandra da Silva, Keith D. Phan, Soizic Riche, Samantha J. Butler
Journal of Neuroscience 20 November 2019, 39 (47) 9316-9327; DOI: 10.1523/JNEUROSCI.0648-19.2019
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Keywords

  • axon
  • development
  • limk1/cofilin
  • regeneration
  • sciatic nerve
  • spinal cord

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