Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses

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¹National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892,
²Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China 510515,
³Biological Sciences Graduate Program, College of Computer, Mathematical, and Natural Sciences, University of Maryland, College Park, Maryland 20740, and
⁴Flaum Eye Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Z. Zhang's present address: Office of Genetic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993.

Author contributions: Y.-H.J., X.-S.W., B.S., L.G., Z.C., and L.-G.W. designed research; Y.-H.J., X.-S.W., B.S., Z.Z., and X.G. performed research; Y.-H.J., X.-S.W., B.S., and Z.Z. analyzed data; B.S. and L.-G.W. edited the paper; L.G. and Z.C. contributed unpublished reagents/analytic tools; L.-G.W. wrote the first draft of the paper; L.-G.W. wrote the paper.
↵*Y.-H.J, X.-S.W., and B.S. contributed equally to this work.

Z. Zhang's present address: Office of Genetic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993.

This work was supported by the National Institutes of Health (NIH)–National Institute of Neurological Disorders and Stroke Intramural Research Program. Y.-H.J. is in the individual graduate partnership program between NIH and Southern Medical University, Guangzhou, China. We thank Yongling Zhu for providing SypH plasmid and Susan Cheng, Virginia Crocker, and Sandra Lara for EM technical support.
The authors declare no competing financial interests.
Correspondence should be addressed to Ling-Gang Wu at wul{at}ninds.nih.gov