Article Information
- Received June 15, 2019
- Revision received September 10, 2019
- Accepted October 7, 2019
- Published in print November 27, 2019.
Author Information
Author contributions
Author contributions: V.R., S.W., J.S., R.B., O.L., T.P., U.G., J.C., and D.M.M. performed research; V.R., S.W., J.S., R.B., T.P., U.G., M.G.H., D.M.M., and H.N.Y. analyzed data; V.R. and H.N.Y. wrote the first draft of the paper; S.W., J.S., O.L., T.P., U.G., J.O.J., C.T., H.C.C., M.G.H., D.M.M., and H.N.Y. edited the paper; J.O.J., C.T., and M.G.H. contributed unpublished reagents/analytic tools; H.N.Y. designed research; H.N.Y. wrote the paper.
↵*V.R. and S.W. contributed equally to this work.
Disclosures
- Received June 15, 2019.
- Revision received September 10, 2019.
- Accepted October 7, 2019.
Confocal microscopy was performed at the Cell and Tissue Imaging Core of the USC Research Center for Liver Diseases, which is supported by the National Institutes of Health (NIH Grant P30 DK048522). H.Y. was supported by Grants R21AG056518[scap], R01AG055770[scap], and R01AG054434 from the National Institute of Aging–NIH. This work was also supported by NIH Grant P50AG05142 to H.C.C. M.G.H. was supported by the L.K. Whittier Foundation. We thank David Holtzman for the immortalized astrocytes, Alan Remaley for HeLa cells, Ashley Martinez for providing Figure 10, and Caleb Finch for critically reviewing the manuscript.
J.O.J. is founder and CEO of Artery Therapeutics, Inc. The remaining authors declare no competing interests.
- Correspondence should be addressed to Hussein N. Yassine at hyassine{at}usc.edu
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