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Research Articles, Neurobiology of Disease

Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons

Grace I. Hallinan, Mariana Vargas-Caballero, Jonathan West and Katrin Deinhardt
Journal of Neuroscience 27 November 2019, 39 (48) 9623-9632; DOI: https://doi.org/10.1523/JNEUROSCI.1590-19.2019
Grace I. Hallinan
1Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom, and
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Mariana Vargas-Caballero
1Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom, and
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Jonathan West
2Faculty of Medicine and Centre for Hybrid Biodevices, Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
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Katrin Deinhardt
1Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1590-19.2019
PubMed 
31658988
Published By 
Society for Neuroscience
History 
  • Received July 5, 2019
  • Revision received September 28, 2019
  • Accepted October 1, 2019
  • Published in print November 27, 2019.
Copyright & Usage 
Copyright © 2019 the authors

Author Information

  1. Grace I. Hallinan1,
  2. Mariana Vargas-Caballero1,
  3. Jonathan West2, and
  4. Katrin Deinhardt1
  1. 1Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom, and
  2. 2Faculty of Medicine and Centre for Hybrid Biodevices, Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
  • G. I. Hallinan's present address: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202.

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Author contributions

  1. Author contributions: G.I.H., M.V.-C., J.W., and K.D. designed research; G.I.H. and M.V.-C. performed research; G.I.H., M.V.-C., and K.D. analyzed data; K.D. wrote the paper.

  • G. I. Hallinan's present address: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202.

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Disclosures

    • Received July 5, 2019.
    • Revision received September 28, 2019.
    • Accepted October 1, 2019.
  • This work was supported by Alzheimer's Research UK (Grants ARUK-PhD2014-10 and ARUK-PPG2017B-001) and the Biotechnology and Biological Sciences Research Council (BB/L007576/1). We thank Vincent O'Connor, Dr. Amrit Mudher, and Aleksandra Pitera for critically reading the paper.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Katrin Deinhardt at K.Deinhardt{at}soton.ac.uk

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The Journal of Neuroscience: 39 (48)
Journal of Neuroscience
Vol. 39, Issue 48
27 Nov 2019
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Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons
Grace I. Hallinan, Mariana Vargas-Caballero, Jonathan West, Katrin Deinhardt
Journal of Neuroscience 27 November 2019, 39 (48) 9623-9632; DOI: 10.1523/JNEUROSCI.1590-19.2019

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Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons
Grace I. Hallinan, Mariana Vargas-Caballero, Jonathan West, Katrin Deinhardt
Journal of Neuroscience 27 November 2019, 39 (48) 9623-9632; DOI: 10.1523/JNEUROSCI.1590-19.2019
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Keywords

  • Alzheimer's disease
  • microfluidic devices
  • prion-like propagation
  • seeding
  • tau

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