Article Information
- Received December 4, 2019
- Revision received February 4, 2020
- Accepted February 5, 2020
- First published February 13, 2020.
- Version of record published March 25, 2020.
Author Information
- Javier Rodriguez-Moreno1,
- Cesar Porrero1,
- Astrid Rollenhagen2,
- Mario Rubio-Teves1,
- Diana Casas-Torremocha1,
- Lidia Alonso-Nanclares3,
- Rachida Yakoubi2,
- Andrea Santuy3,
- Angel Merchan-Pérez3,5,6,
- Javier DeFelipe3,4,5,
- Joachim H.R. Lübke2,7,8,*, and
- Francisco Clasca1,*
- 1Department of Anatomy and Neuroscience, School of Medicine, Autónoma de Madrid University, 28029 Madrid, Spain,
- 2Institute of Neuroscience and Medicine INM-10, Research Centre Jülich GmbH, 52425 Jülich, Germany,
- 3Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, Spain,
- 4Instituto Cajal, Consejo Superior de Investigaciones Científicas, Arce 37 28002, Madrid, Spain,
- 5CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, 28031 Madrid, Spain,
- 6Departamento de Arquitectura y Tecnología de Sistemas Informáticos, Universidad Politécnica de Madrid. Boadilla del Monte, 28660 Madrid, Spain,
- 7Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty RWTH University Hospital Aachen, 52074 Aachen, Germany, and
- 8JARA-Translational Brain Medicine, 52425 Jülich-Aachen, Germany
Author contributions
Author contributions: J.R.-M., C.P., D.C.-T., and F.C. designed research; J.R.-M., C.P., A.R., M.R.-T., L.A.-N., A.S., and A.M.-P. performed research; J.D. and J.H.L. contributed unpublished reagents/analytic tools; J.R.-M., C.P., A.R., M.R.-T., R.Y., J.H.R.L., and F.C. analyzed data; J.R.-M., C.P., D.C.-T., J.D., J.H.R.L., and F.C. wrote the paper; paper.
↵*J.H.R.L. and F.C. contributed equally as co-senior authors.
Disclosures
- Received December 4, 2019.
- Revision received February 4, 2020.
- Accepted February 5, 2020.
This work was supported by the European Union's Horizon 2020 Research and Innovation Programme (Grant 785907 HBP SGA2), by Spain's Ministerio de Ciencia, Innovación y Universidades (BFU 2107-88549-P) to F.C., and by Grants of the Helmholtz Society (JHRL). We thank Begoña Rodriguez, Marta Callejo, Brigitte Marshallsay, and Tafun Palaz for excellent technical help.
The data that support the findings of this study are available from the corresponding author upon reasonable request. In addition, all serial electron microscope image stacks will be made available before publication in the Human Brain Project Graph Data Platform (https://www.humanbrainproject.eu/explore-the-brain/search) under a CC-BY license.
The authors declare no competing financial interests.
- Correspondence should be addressed to Francisco Clasca at francisco.clasca{at}uam.es
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