About the Cover
Cover image

This image shows the perineurial glia that ensheath the nervous system in Drosophila. Perlecan tagged with GFP (green) marks the extracellular matrix that tightly associates with the perineurial glia (labeled with a red, RFP-tagged membrane marker). The perineurial glia in turn ensheath the entire peripheral nerve including the peripheral axons (labeled in blue) at the core of each nerve. The transmembrane protein Basigin interacts with integrins at focal adhesions to regulate the interaction of integrins with the extracellular matrix, and loss of Basigin leads to compression of the peripheral nerve. For more information, see the article by Hunter et al. (pages 3360–3373).