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Featured ArticleResearch Articles, Systems/Circuits

A VTA to Basal Amygdala Dopamine Projection Contributes to Signal Salient Somatosensory Events during Fear Learning

Wei Tang, Olexiy Kochubey, Michael Kintscher and Ralf Schneggenburger
Journal of Neuroscience 13 May 2020, 40 (20) 3969-3980; DOI: https://doi.org/10.1523/JNEUROSCI.1796-19.2020
Wei Tang
1Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland
2Bernstein Center for Computational Neuroscience, Humboldt University of Berlin, Berlin, 10115, Germany
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Olexiy Kochubey
1Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland
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Michael Kintscher
1Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland
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Ralf Schneggenburger
1Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1796-19.2020
PubMed 
32277045
Published By 
Society for Neuroscience
History 
  • Received July 26, 2019
  • Revision received March 25, 2020
  • Accepted March 26, 2020
  • First published April 10, 2020.
  • Version of record published May 13, 2020.
Copyright & Usage 
Copyright © 2020 the authors

Author Information

  1. Wei Tang1,2,
  2. Olexiy Kochubey1,
  3. Michael Kintscher1, and
  4. Ralf Schneggenburger1
  1. 1Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland
  2. 2Bernstein Center for Computational Neuroscience, Humboldt University of Berlin, Berlin, 10115, Germany
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Author contributions

  1. Author contributions: W.T., O.K., M.K., and R.S. designed research; W.T., O.K., and M.K. performed research; W.T., O.K., and M.K. analyzed data; W.T. wrote the first draft of the paper; W.T., O.K., M.K., and R.S. edited the paper; R.S. wrote the paper.

Disclosures

    • Received July 26, 2019.
    • Revision received March 25, 2020.
    • Accepted March 26, 2020.
  • The authors declare no competing financial interests.

  • This work was supported by Swiss National Science Foundation (SNSF) 31003A_176332/1 to R.S., SNSF National Competence Center for Research Synapsy, Synaptic Bases of Mental Disease Project 28 to R.S., and EMBO Fellowship ALTF 224-2015 to M.K. Image acquisition was done at the Bioimaging & Optics Platform of École Polytechnique Fédérale de Lausanne (Bioimaging and Optics Platform). We thank Heather Murray, Tess Baticle, and Jessica Dupasquier for expert technical assistance; and Dr. Bernard Schneider (École Polytechnique Fédérale de Lausanne) for help with AAV vector packaging.

  • Correspondence should be addressed to Ralf Schneggenburger at ralf.schneggenburger{at}epfl.ch

Other Version

  • previous version (April 10, 2020).
  • You are viewing the most recent version of this article.

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May 20203342316295
Jun 202077711494
Jul 20204808151
Aug 20202203932
Sep 20202665850
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Feb 20233514152
Mar 20232610536
Total 2023106364137
Total638948592453
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The Journal of Neuroscience: 40 (20)
Journal of Neuroscience
Vol. 40, Issue 20
13 May 2020
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A VTA to Basal Amygdala Dopamine Projection Contributes to Signal Salient Somatosensory Events during Fear Learning
Wei Tang, Olexiy Kochubey, Michael Kintscher, Ralf Schneggenburger
Journal of Neuroscience 13 May 2020, 40 (20) 3969-3980; DOI: 10.1523/JNEUROSCI.1796-19.2020

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A VTA to Basal Amygdala Dopamine Projection Contributes to Signal Salient Somatosensory Events during Fear Learning
Wei Tang, Olexiy Kochubey, Michael Kintscher, Ralf Schneggenburger
Journal of Neuroscience 13 May 2020, 40 (20) 3969-3980; DOI: 10.1523/JNEUROSCI.1796-19.2020
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Keywords

  • amygdala
  • auditory conditioning
  • dopamine
  • fear memory
  • optogenetics
  • VTA

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