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Cover ArticleResearch Articles, Development/Plasticity/Repair

Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis

Victor Danelon, Ron Goldner, Edward Martinez, Irena Gokhman, Kimberly Wang, Avraham Yaron and Tracy S. Tran
Journal of Neuroscience 8 July 2020, 40 (28) 5413-5430; DOI: https://doi.org/10.1523/JNEUROSCI.2730-19.2020
Victor Danelon
1Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102
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Ron Goldner
2Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel
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Edward Martinez
1Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102
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Irena Gokhman
2Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel
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Kimberly Wang
1Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102
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Avraham Yaron
2Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel
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Tracy S. Tran
1Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2730-19.2020
PubMed 
32499377
Published By 
Society for Neuroscience
History 
  • Received November 17, 2019
  • Revision received April 29, 2020
  • Accepted May 26, 2020
  • First published June 4, 2020.
  • Version of record published July 8, 2020.
Copyright & Usage 
Copyright © 2020 the authors

Author Information

  1. Victor Danelon1,*,
  2. Ron Goldner2,*,
  3. Edward Martinez1,
  4. Irena Gokhman2,
  5. Kimberly Wang1,
  6. Avraham Yaron2, and
  7. Tracy S. Tran1
  1. 1Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102
  2. 2Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel
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Author contributions

  1. Author contributions: V.D., R.G., E.M., I.G., and K.W. performed research; V.D., R.G., A.Y., and T.S.T. analyzed data; V.D. and R.G. wrote the first draft of the paper; V.D., R.G., A.Y., and T.S.T. edited the paper; A.Y. and T.S.T. designed research; A.Y. and T.S.T. wrote the paper.

  2. ↵*V.D. and R.G. contributed equally to this work.

Disclosures

    • Received November 17, 2019.
    • Revision received April 29, 2020.
    • Accepted May 26, 2020.
  • The authors declare no competing financial interests.

  • This work was support by National Science Foundation Integrative Organismal Systems BOI Grant 1556968 and BSF Grant 2013052 to T.S.T. and A.Y. Research in the laboratory of T.S.T. was also supported by the New Jersey Governor's Council for Medical Research and Treatment of Autism Grant CAUT17BSP022, the New Jersey Commission on Spinal Cord Research Grant CSCR16IRG013, and Rutgers University Newark Chancellor's Initiative for Multidisciplinary Research Teams Award. Research in the laboratory of A.Y. was supported by the Jeanne and Joseph Nissim Center for Life Sciences Research at the Weizmann Institute of Science and the Nella and Leon Benoziyo Center for Neurologic Diseases. A.Y. is an incumbent of the Jack and Simon Djanogly Professorial Chair in Biochemistry. We thank Alex Kolodkin and Oren Schuldiner for providing critical feedback to this work; and Adefemi Baderinwa and Michelle Davis for excellent technical support with mouse genotyping.

  • Correspondence should be addressed to Tracy S. Tran at tstran{at}rutgers.edu or Avraham Yaron at avraham.yaron{at}weizmann.ac.il

Funding

  • National Science Foundation (NSF)

    1556968
  • United States - Israel Binational Science Foundation (BSF)

    2013052

Other Version

  • previous version (June 04, 2020).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 40 (28)
Journal of Neuroscience
Vol. 40, Issue 28
8 Jul 2020
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Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis
Victor Danelon, Ron Goldner, Edward Martinez, Irena Gokhman, Kimberly Wang, Avraham Yaron, Tracy S. Tran
Journal of Neuroscience 8 July 2020, 40 (28) 5413-5430; DOI: 10.1523/JNEUROSCI.2730-19.2020

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Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis
Victor Danelon, Ron Goldner, Edward Martinez, Irena Gokhman, Kimberly Wang, Avraham Yaron, Tracy S. Tran
Journal of Neuroscience 8 July 2020, 40 (28) 5413-5430; DOI: 10.1523/JNEUROSCI.2730-19.2020
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Keywords

  • axonal repulsion
  • dendritic branching
  • guidance receptors
  • neural development
  • Semaphorin signaling

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