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Featured ArticleResearch Articles, Development/Plasticity/Repair

Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury

Chelsey B. Reed, Luciana R. Frick, Adam Weaver, Mariapaola Sidoli, Elizabeth Schlant, M. Laura Feltri and Lawrence Wrabetz
Journal of Neuroscience 5 August 2020, 40 (32) 6165-6176; DOI: https://doi.org/10.1523/JNEUROSCI.0951-20.2020
Chelsey B. Reed
1Hunter James Kelly Research Institute
2Department of Neurology
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Luciana R. Frick
1Hunter James Kelly Research Institute
2Department of Neurology
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Adam Weaver
1Hunter James Kelly Research Institute
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Mariapaola Sidoli
1Hunter James Kelly Research Institute
3Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
4Department of Developmental Biology, School of Medicine, Stanford University, Stanford, California 94305
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Elizabeth Schlant
1Hunter James Kelly Research Institute
3Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
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M. Laura Feltri
1Hunter James Kelly Research Institute
2Department of Neurology
3Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
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Lawrence Wrabetz
1Hunter James Kelly Research Institute
2Department of Neurology
3Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0951-20.2020
PubMed 
32641402
Published By 
Society for Neuroscience
History 
  • Received April 22, 2020
  • Revision received June 9, 2020
  • Accepted June 20, 2020
  • First published July 8, 2020.
  • Version of record published August 5, 2020.
Copyright & Usage 
Copyright © 2020 the authors

Author Information

  1. Chelsey B. Reed1,2,
  2. Luciana R. Frick1,2,
  3. Adam Weaver1,
  4. Mariapaola Sidoli1,3,4,
  5. Elizabeth Schlant1,3,
  6. M. Laura Feltri1,2,3, and
  7. Lawrence Wrabetz1,2,3
  1. 1Hunter James Kelly Research Institute
  2. 2Department of Neurology
  3. 3Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
  4. 4Department of Developmental Biology, School of Medicine, Stanford University, Stanford, California 94305
View Full Text

Author contributions

  1. Author contributions: C.B.R., L.R.F., E.S., and M.L.F. analyzed data; C.B.R., E.S., and M.L.F. edited the paper; C.B.R., L.R.F., and M.L.F. wrote the paper; L.R.F., M.L.F., and L.W. designed research; L.R.F., A.W., M.S., E.S., and L.W. performed research; L.R.F. wrote the first draft of the paper.

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Disclosures

    • Received April 22, 2020.
    • Revision received June 9, 2020.
    • Accepted June 20, 2020.
  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants R01-NS NS55256 and R56NS096104 to L.W., Grant F30NS105405-02 to C.B.R., and Grant R01NS100464 to M.L.F. We thank Ed Hurley for the processing of sciatic nerves for semithin and electron microscopy; Dies Meijer (University of Edinburgh) for KROX20 and OCT6 antibodies; and Nadav Weinstock for useful discussion and time spent imaging nerve sections on the confocal microscope.

  • Correspondence should be addressed to M. Laura Feltri at mlfeltri{at}buffalo.edu

Funding

  • NIH-NINDS

    R01-NS NS55256; R56NS096104; F30NS105405

Other Version

  • previous version (July 08, 2020).
  • You are viewing the most recent version of this article.

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Jul 2020883062
Aug 202013179463
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Nov 2020120139
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Total 20202994173187
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Total 202187128
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The Journal of Neuroscience: 40 (32)
Journal of Neuroscience
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5 Aug 2020
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Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury
Chelsey B. Reed, Luciana R. Frick, Adam Weaver, Mariapaola Sidoli, Elizabeth Schlant, M. Laura Feltri, Lawrence Wrabetz
Journal of Neuroscience 5 August 2020, 40 (32) 6165-6176; DOI: 10.1523/JNEUROSCI.0951-20.2020

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Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury
Chelsey B. Reed, Luciana R. Frick, Adam Weaver, Mariapaola Sidoli, Elizabeth Schlant, M. Laura Feltri, Lawrence Wrabetz
Journal of Neuroscience 5 August 2020, 40 (32) 6165-6176; DOI: 10.1523/JNEUROSCI.0951-20.2020
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Keywords

  • autophagy
  • calcineurin
  • myelin
  • nerve injury
  • nerve regeneration
  • Schwann cell

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