Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury

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¹Hunter James Kelly Research Institute
²Department of Neurology
³Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
⁴Department of Developmental Biology, School of Medicine, Stanford University, Stanford, California 94305

Author contributions: C.B.R., L.R.F., E.S., and M.L.F. analyzed data; C.B.R., E.S., and M.L.F. edited the paper; C.B.R., L.R.F., and M.L.F. wrote the paper; L.R.F., M.L.F., and L.W. designed research; L.R.F., A.W., M.S., E.S., and L.W. performed research; L.R.F. wrote the first draft of the paper.

The authors declare no competing financial interests.
This work was supported by National Institutes of Health Grants R01-NS NS55256 and R56NS096104 to L.W., Grant F30NS105405-02 to C.B.R., and Grant R01NS100464 to M.L.F. We thank Ed Hurley for the processing of sciatic nerves for semithin and electron microscopy; Dies Meijer (University of Edinburgh) for KROX20 and OCT6 antibodies; and Nadav Weinstock for useful discussion and time spent imaging nerve sections on the confocal microscope.
Correspondence should be addressed to M. Laura Feltri at mlfeltri{at}buffalo.edu