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Research Articles, Cellular/Molecular

Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning

Thomas Andreska, Stefanie Rauskolb, Nina Schukraft, Patrick Lüningschrör, Manju Sasi, Jeremy Signoret-Genest, Marcus Behringer, Robert Blum, Markus Sauer, Philip Tovote and Michael Sendtner
Journal of Neuroscience 12 August 2020, 40 (33) 6289-6308; DOI: https://doi.org/10.1523/JNEUROSCI.0288-20.2020
Thomas Andreska
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Stefanie Rauskolb
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Nina Schukraft
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Patrick Lüningschrör
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Manju Sasi
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Jeremy Signoret-Genest
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Marcus Behringer
2Department of Biotechnology and Biophysics, Julius-Maximilians-University Wuerzburg, 97074 Wuerzburg, Germany
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Robert Blum
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Markus Sauer
2Department of Biotechnology and Biophysics, Julius-Maximilians-University Wuerzburg, 97074 Wuerzburg, Germany
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Philip Tovote
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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Michael Sendtner
1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
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  • ORCID record for Michael Sendtner
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0288-20.2020
PubMed 
32651187
Published By 
Society for Neuroscience
History 
  • Received February 6, 2020
  • Revision received June 9, 2020
  • Accepted June 25, 2020
  • First published July 10, 2020.
  • Version of record published August 12, 2020.
Copyright & Usage 
Copyright © 2020 Andreska et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Thomas Andreska1,
  2. Stefanie Rauskolb1,
  3. Nina Schukraft1,
  4. Patrick Lüningschrör1,
  5. Manju Sasi1,
  6. Jeremy Signoret-Genest1,
  7. Marcus Behringer2,
  8. Robert Blum1,
  9. Markus Sauer2,
  10. Philip Tovote1, and
  11. Michael Sendtner1
  1. 1Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
  2. 2Department of Biotechnology and Biophysics, Julius-Maximilians-University Wuerzburg, 97074 Wuerzburg, Germany
View Full Text

Author contributions

  1. Author contributions: T.A., S.R., P.L., R.B., M. Sauer, P.T., and M. Sendtner designed research; T.A., S.R., N.S., P.L., M. Sasi, J.S.-G., M.B., and R.B. performed research; T.A., S.R., P.L., J.S.-G., M.B., R.B., and M. Sendtner analyzed data; T.A., S.R., and M. Sendtner wrote the first draft of the paper; T.A., S.R., and M. Sendtner edited the paper; T.A., S.R., and M. Sendtner wrote the paper.

Disclosures

    • Received February 6, 2020.
    • Revision received June 9, 2020.
    • Accepted June 25, 2020.
  • The authors declare no competing financial interests.

  • This work was supported by Deutsche Forschungsgemeinschaft TRR 58, Project A09, and Project SE 697/7-1; Deutsche Forschungsgemeinschaft preparatory grant TRR 295 and A05; and Bundesministerium für Bildung und Forschung (through the EnergI Consortium). We thank Drs. Francis Lee, Anders Nykjær, and Volkmar Leßmann for critical comments and suggestions; and Dr. Tonnis Timmusk for providing the 4C8, 3C11, and 3B2 monoclonal BDNF antibodies.

  • Correspondence should be addressed to Thomas Andreska at Andreska_T{at}ukw.de

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

    TRR 58; Project A09; SE 697/7-1; TRR295
  • Bundesministerium für Bildung und Forschung (BMBF)

    EnergI
  • Schilling Stiftung

Other Version

  • previous version (July 10, 2020).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 40 (33)
Journal of Neuroscience
Vol. 40, Issue 33
12 Aug 2020
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Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning
Thomas Andreska, Stefanie Rauskolb, Nina Schukraft, Patrick Lüningschrör, Manju Sasi, Jeremy Signoret-Genest, Marcus Behringer, Robert Blum, Markus Sauer, Philip Tovote, Michael Sendtner
Journal of Neuroscience 12 August 2020, 40 (33) 6289-6308; DOI: 10.1523/JNEUROSCI.0288-20.2020

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Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning
Thomas Andreska, Stefanie Rauskolb, Nina Schukraft, Patrick Lüningschrör, Manju Sasi, Jeremy Signoret-Genest, Marcus Behringer, Robert Blum, Markus Sauer, Philip Tovote, Michael Sendtner
Journal of Neuroscience 12 August 2020, 40 (33) 6289-6308; DOI: 10.1523/JNEUROSCI.0288-20.2020
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Keywords

  • BDNF
  • motor cortex
  • motor learning
  • neurotrophic factor
  • striatum

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