This image shows neuromuscular junctions in tibialis anterior (TA) muscle of a 60 day old C57/BL6 mouse. The nerve terminal was stained with neurofilament and synapsin antibodies (green), and acetylcholine receptor clusters were visualized with CF568 α-bungarotoxin (red). Acetylcholine receptor clusters went through fragmentation and denervation during aging. New work investigated the molecular mechanisms underlying this decline. For more information, see the article by Gao, Zhao et al. (pages 7203–7215). Cover Image: Mei Lab.