Article Information
- Received January 12, 2020
- Revision received August 21, 2020
- Accepted August 31, 2020
- First published September 10, 2020.
- Version of record published September 30, 2020.
Author Information
- Himari Ogino1,
- Tsuzumi Nakajima1,
- Yuki Hirota2,
- Kohki Toriuchi3,
- Mineyoshi Aoyama3,
- Kazunori Nakajima2, and
- Mitsuharu Hattori1
- 1Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
- 2Department of Anatomy, Keio University School of Medicine, Tokyo 160-8582, Japan
- 3Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
Author contributions
Author contributions: H.O. and M.H. designed research; H.O., T.N., Y.H., and K.T. performed research; H.O., T.N., and M.H. analyzed data; H.O., M.A., K.N., and M.H. wrote the paper.
Disclosures
- Received January 12, 2020.
- Revision received August 21, 2020.
- Accepted August 31, 2020.
This work was supported by JSPS Grants-in-Aid for Scientific Research 17H03895, 17K19500, and JP20H03384 (to M.H.), 16K10101 (to M.A.), 16H06482 (to K.N.), 17K07415 (to Y.H.), and 17J10967 (to H.O.); ACT-M (ACceleration Transformative research for Medical innovation) Grants 16im0210602h0001 and 17im0210602h0002 of the Japan Agency for Medical Research and Development (to M.H.); Takeda Science Foundation (K.N.); Keio Gijuku Academic Development Funds (K.N.); Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research (K.N.); and Ono Medical Research Foundation (M.H.). H.O. is Research Fellow of Japan Society for the Promotion of Science (DC1).
We thank Drs. Tom Curran (Children's Research Institute at Children's Mercy Hospital, MO, USA), Junichi Takagi (Osaka University, Japan), and Katsuhiko Mikoshiba (ShanghaiTech University, China) for generously providing reagents. We greatly appreciate Prof. Masahiro Tohkin (Nagoya City University) for his professional advice on the statistical analyses. We thank Drs. Takao Kohno, Hitomi Tsuiji (Nagoya City University), Tadashi Nomura, Hitoshi Gotoh, Katsuhiko Ono (Kyoto Prefectural University of Medicine), and Rieko Muramatsu (National Center for Neurology and Psychiatry, Japan) for their insightful comments.
The authors declare no competing financial interests.
- Correspondence should be addressed to Mitsuharu Hattori at mhattori{at}phar.nagoya-cu.ac.jp
Funding
Japan Society for the Promotion of Science (JSPS)
17H03895; 17K19500; 16K10101; 16H06482; 17K07415; 17J10967Japan Agency for Medical Research and Development (AMED)
16im0210602h0001; 17im0210602h0002Takeda Science Foundation
Keio Gijuku Academic Development Funds
Keio Gijuku Fukuzawa Memorial Fund
Ono Medical Research Foundation
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