The Notch Ligand Jagged1 Is Required for the Formation, Maintenance, and Survival of Hensen's Cells in the Mouse Cochlea

Article Information

DOI

PubMed

Published By

History

¹Solomon H. Snyder Department of Neuroscience and
²Center for Hearing and Balance, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
³Departments of Pharmacology
⁴Otolaryngology, Southern Illinois University School of Medicine, Springfield, Illinois 62702

Author contributions: E.C., L.Z., Y.L.D., and K.A.G. performed research; E.C., L.Z., Y.L.D., K.A.G., A.D., and B.C.C. analyzed data; A.D. and B.C.C. wrote the paper; E.C. and L.Z. wrote the first draft of the paper; L.Z., A.D., and B.C.C. edited the paper; A.D. and B.C.C. designed research.
↵*E.C. and L.Z. contributed equally to this work as co-first authors.

This work was supported by National Institute on Deafness and Other Communication Disorders Grants R01DC011571 to A.D. and R01DC014441 to B.C.C., and the Office of the Assistant Secretary of Defense for Health Affairs Grant W81XWH-15-1-0475 to B.C.C. The Southern Illinois University School of Medicine Research Imaging Facility is supported by Office of Naval Research Grant N00014-15-1-2866. We thank Dr. William Richardson (University College London) for providing the Fgfr3-iCreER^T2 mouse line; and Dr. Julian Lewis (Cancer Research UK London Research Institute) for providing one of the Jag1^fx/fx mouse lines.
B.C.C. is a consultant for Turner Scientific, LLC, and Otonomy, Inc. The remaining authors declare no competing financial interests.
Correspondence should be addressed to Angelika Doetzlhofer at adoetzlhofer{at}jhmi.edu or Brandon C. Cox at bcox{at}siumed.edu

HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)
R01DC011571; R01DC014441
Office of the Assistant Secretary of Defense for Health Affairs
W81XWH-15-1-0475
DOD | United States Navy | Office of Naval Research (ONR)
N00014-15-1-2866