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Research Articles, Systems/Circuits

Complementary Inhibitory Weight Profiles Emerge from Plasticity and Allow Flexible Switching of Receptive Fields

Everton J. Agnes, Andrea I. Luppi and Tim P. Vogels
Journal of Neuroscience 9 December 2020, 40 (50) 9634-9649; DOI: https://doi.org/10.1523/JNEUROSCI.0276-20.2020
Everton J. Agnes
1Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, OX1 3SR, United Kingdom
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Andrea I. Luppi
1Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, OX1 3SR, United Kingdom
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Tim P. Vogels
1Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, OX1 3SR, United Kingdom
2Institute of Science and Technology Austria, Klosterneuburg, 3400, Austria
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0276-20.2020
PubMed 
33168622
Published By 
Society for Neuroscience
History 
  • Received February 5, 2020
  • Revision received July 6, 2020
  • Accepted July 12, 2020
  • First published November 9, 2020.
  • Version of record published December 9, 2020.
Copyright & Usage 
Copyright © 2020 Agnes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Everton J. Agnes1,
  2. Andrea I. Luppi1, and
  3. Tim P. Vogels1,2
  1. 1Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, OX1 3SR, United Kingdom
  2. 2Institute of Science and Technology Austria, Klosterneuburg, 3400, Austria
  • A.I. Luppi's present address: Department of Clinical Neurosciences, University of Cambridge, CB2 0QQ Cambridge, United Kingdom.

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Author contributions

  1. Author contributions: E.J.A. and T.P.V. designed research; E.J.A. and A.I.L. performed research; E.J.A. analyzed data; E.J.A., A.I.L., and T.P.V. wrote the paper.

  • A.I. Luppi's present address: Department of Clinical Neurosciences, University of Cambridge, CB2 0QQ Cambridge, United Kingdom.

Disclosures

    • Received February 5, 2020.
    • Revision received July 6, 2020.
    • Accepted July 12, 2020.
  • This work was supported by Leverhulme Trust Research Project Grant RPG-2016-446 to E.J.A., Wellcome Trust and the Royal Society Sir Henry Dale Fellowship WT100000 to E.J.A. and T.P.V., Wellcome Trust Senior Research Fellowship 214316/Z/18/Z to E.J.A. and T.P.V., ERC Consolidator Grant SYNAPSEEK to E.J.A. and T.P.V., and University of Oxford Claredon Scholarship to A.I.L. We thank the members of the Vogels group, and particularly Georgia Christodoulou and William Podlaski, for fruitful discussions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Everton J. Agnes at everton.agnes{at}gmail.com

Funding

  • Leverhulme Trust

    RPG-2016-446
  • Wellcome Trust and Royal Society

    WT100000
  • Wellcome Trust (Wellcome)

    214316/Z/18/Z
  • University Of Oxford

    Claredon Scholarship
  • EC | European Research Council (ERC)

    SYNAPSEEK

Other Version

  • previous version (November 09, 2020).
  • You are viewing the most recent version of this article.

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Nov 2020661079
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Total 20201542590239
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Jul 2021254528
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Feb 2023182915
Mar 2023142816
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Jun 202310288
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The Journal of Neuroscience: 40 (50)
Journal of Neuroscience
Vol. 40, Issue 50
9 Dec 2020
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Complementary Inhibitory Weight Profiles Emerge from Plasticity and Allow Flexible Switching of Receptive Fields
Everton J. Agnes, Andrea I. Luppi, Tim P. Vogels
Journal of Neuroscience 9 December 2020, 40 (50) 9634-9649; DOI: 10.1523/JNEUROSCI.0276-20.2020

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Complementary Inhibitory Weight Profiles Emerge from Plasticity and Allow Flexible Switching of Receptive Fields
Everton J. Agnes, Andrea I. Luppi, Tim P. Vogels
Journal of Neuroscience 9 December 2020, 40 (50) 9634-9649; DOI: 10.1523/JNEUROSCI.0276-20.2020
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Keywords

  • cortex
  • disinhibition
  • EI balance
  • receptive field
  • synaptic plasticity

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