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Research Articles, Cellular/Molecular

Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System

Maryna Samus, Yu-Tung Li, Lydia Sorokin, Klemens Rottner and Dietmar Vestweber
Journal of Neuroscience 12 February 2020, 40 (7) 1389-1404; https://doi.org/10.1523/JNEUROSCI.1266-19.2019
Maryna Samus
1Max-Planck Institute for Molecular Biomedicine, D48149 Münster, Germany,
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Yu-Tung Li
1Max-Planck Institute for Molecular Biomedicine, D48149 Münster, Germany,
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Lydia Sorokin
2Institute of Physiological Chemistry and Pathobiochemistry D48149 Münster, Germany,
3Cells-in-Motion Cluster of Excellence, University of Münster, 48149 Münster, Germany,
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  • ORCID record for Lydia Sorokin
Klemens Rottner
4Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany, and
5Technische Universität Braunschweig, 38106 Braunschweig, Germany
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Dietmar Vestweber
1Max-Planck Institute for Molecular Biomedicine, D48149 Münster, Germany,
3Cells-in-Motion Cluster of Excellence, University of Münster, 48149 Münster, Germany,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1266-19.2019
PubMed 
31911458
Published By 
Society for Neuroscience
History 
  • Received May 31, 2019
  • Revision received December 4, 2019
  • Accepted December 19, 2019
  • First published January 7, 2020.
  • Version of record published February 12, 2020.
Copyright & Usage 
Copyright © 2020 the authors

Author Information

  1. Maryna Samus1,
  2. Yu-Tung Li1,
  3. Lydia Sorokin2,3,
  4. Klemens Rottner4,5, and
  5. Dietmar Vestweber1,3
  1. 1Max-Planck Institute for Molecular Biomedicine, D48149 Münster, Germany,
  2. 2Institute of Physiological Chemistry and Pathobiochemistry D48149 Münster, Germany,
  3. 3Cells-in-Motion Cluster of Excellence, University of Münster, 48149 Münster, Germany,
  4. 4Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany, and
  5. 5Technische Universität Braunschweig, 38106 Braunschweig, Germany
View Full Text

Author contributions

  1. Author contributions: M.S. and Y.-T.L. performed research; M.S. and D.V. analyzed data; M.S. wrote the first draft of the paper; Y.-T.L., L.S., and K.R. edited the paper; L.S. and K.R. contributed unpublished reagents/analytic tools; D.V. designed research; D.V. wrote the paper.

Disclosures

    • Received May 31, 2019.
    • Revision received December 4, 2019.
    • Accepted December 19, 2019.
  • This work was supported in part by the Max Planck Society to D.V. and Deutsche Forschungsgemeinschaft SFB/TR128 to D.V.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dietmar Vestweber at vestweb{at}mpi-muenster.mpg.de

Other Version

  • previous version (January 07, 2020).
  • You are viewing the most recent version of this article.

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Total 20253314170
Total343826371332
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The Journal of Neuroscience: 40 (7)
Journal of Neuroscience
Vol. 40, Issue 7
12 Feb 2020
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Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System
Maryna Samus, Yu-Tung Li, Lydia Sorokin, Klemens Rottner, Dietmar Vestweber
Journal of Neuroscience 12 February 2020, 40 (7) 1389-1404; DOI: 10.1523/JNEUROSCI.1266-19.2019

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Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System
Maryna Samus, Yu-Tung Li, Lydia Sorokin, Klemens Rottner, Dietmar Vestweber
Journal of Neuroscience 12 February 2020, 40 (7) 1389-1404; DOI: 10.1523/JNEUROSCI.1266-19.2019
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Keywords

  • blood–brain barrier
  • leukocyte extravasation
  • multiple sclerosis

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