Cover ArticleResearch Articles, Neurobiology of Disease
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
William J. Meilandt, Hai Ngu, Alvin Gogineni, Guita Lalehzadeh, Seung-Hye Lee, Karpagam Srinivasan, Jose Imperio, Tiffany Wu, Martin Weber, Agatha J. Kruse, Kimberly L. Stark, Pamela Chan, Mandy Kwong, Zora Modrusan, Brad A. Friedman, Justin Elstrott, Oded Foreman, Amy Easton, Morgan Sheng and David V. Hansen
Journal of Neuroscience 26 February 2020, 40 (9) 1956-1974; https://doi.org/10.1523/JNEUROSCI.1871-19.2019
William J. Meilandt
1Departments of Neuroscience,
Hai Ngu
2Pathology,
Alvin Gogineni
3Biomedical Imaging,
Guita Lalehzadeh
1Departments of Neuroscience,
Seung-Hye Lee
1Departments of Neuroscience,
Karpagam Srinivasan
1Departments of Neuroscience,
Jose Imperio
1Departments of Neuroscience,
Tiffany Wu
1Departments of Neuroscience,
Martin Weber
1Departments of Neuroscience,
Agatha J. Kruse
3Biomedical Imaging,
Kimberly L. Stark
1Departments of Neuroscience,
Pamela Chan
5Biochemical and Cellular Pharmacology, and
Mandy Kwong
5Biochemical and Cellular Pharmacology, and
Zora Modrusan
6Molecular Biology, Genentech, Inc., South San Francisco, California 94080
Brad A. Friedman
4Bioinformatics,
Justin Elstrott
3Biomedical Imaging,
Oded Foreman
2Pathology,
Amy Easton
1Departments of Neuroscience,
Morgan Sheng
1Departments of Neuroscience,
David V. Hansen
1Departments of Neuroscience,
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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
William J. Meilandt, Hai Ngu, Alvin Gogineni, Guita Lalehzadeh, Seung-Hye Lee, Karpagam Srinivasan, Jose Imperio, Tiffany Wu, Martin Weber, Agatha J. Kruse, Kimberly L. Stark, Pamela Chan, Mandy Kwong, Zora Modrusan, Brad A. Friedman, Justin Elstrott, Oded Foreman, Amy Easton, Morgan Sheng, David V. Hansen
Journal of Neuroscience 26 February 2020, 40 (9) 1956-1974; DOI: 10.1523/JNEUROSCI.1871-19.2019
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
William J. Meilandt, Hai Ngu, Alvin Gogineni, Guita Lalehzadeh, Seung-Hye Lee, Karpagam Srinivasan, Jose Imperio, Tiffany Wu, Martin Weber, Agatha J. Kruse, Kimberly L. Stark, Pamela Chan, Mandy Kwong, Zora Modrusan, Brad A. Friedman, Justin Elstrott, Oded Foreman, Amy Easton, Morgan Sheng, David V. Hansen
Journal of Neuroscience 26 February 2020, 40 (9) 1956-1974; DOI: 10.1523/JNEUROSCI.1871-19.2019
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