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Featured ArticleResearch Articles, Systems/Circuits

Central Amygdala Projections to Lateral Hypothalamus Mediate Avoidance Behavior in Rats

Marcus M. Weera, Rosetta S. Shackett, Hannah M. Kramer, Jason W. Middleton and Nicholas W. Gilpin
Journal of Neuroscience 6 January 2021, 41 (1) 61-72; DOI: https://doi.org/10.1523/JNEUROSCI.0236-20.2020
Marcus M. Weera
1Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
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Rosetta S. Shackett
1Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
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Hannah M. Kramer
1Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
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Jason W. Middleton
2Department of Cell Biology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
3Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
4Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
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Nicholas W. Gilpin
1Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
3Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
4Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
5Southeast Louisiana VA Healthcare System (SLVHCS), New Orleans, Louisiana 70119
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Abstract

Persistent avoidance of stress-related stimuli following acute stress exposure predicts negative outcomes such as substance abuse and traumatic stress disorders. Previous work using a rat model showed that the central amygdala (CeA) plays an important role in avoidance of a predator odor stress-paired context. Here, we show that CeA projections to the lateral hypothalamus (LH) are preferentially activated in male rats that show avoidance of a predator odor-paired context (termed Avoider rats), that chemogenetic inhibition of CeA-LH projections attenuates avoidance in male Avoider rats, that chemogenetic stimulation of the CeA-LH circuit produces conditioned place avoidance (CPA) in otherwise naive male rats, and that avoidance behavior is associated with intrinsic properties of LH-projecting CeA cells. Collectively, these data show that CeA-LH projections are important for persistent avoidance of stress-related stimuli following acute stress exposure.

SIGNIFICANCE STATEMENT This study in rats shows that a specific circuit in the brain [i.e., neurons that project from the central amygdala (CeA) to the lateral hypothalamus (LH)] mediates avoidance of stress-associated stimuli. In addition, this study shows that intrinsic physiological properties of cells in this brain circuit are associated with avoidance of stress-associated stimuli. Further characterization of the CeA-LH circuit may improve our understanding of the neural mechanisms underlying specific aspects of stress-related disorders in humans.

  • avoidance
  • central amygdala
  • HCN channels
  • lateral hypothalamus
  • stress

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The Journal of Neuroscience: 41 (1)
Journal of Neuroscience
Vol. 41, Issue 1
6 Jan 2021
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Central Amygdala Projections to Lateral Hypothalamus Mediate Avoidance Behavior in Rats
Marcus M. Weera, Rosetta S. Shackett, Hannah M. Kramer, Jason W. Middleton, Nicholas W. Gilpin
Journal of Neuroscience 6 January 2021, 41 (1) 61-72; DOI: 10.1523/JNEUROSCI.0236-20.2020

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Central Amygdala Projections to Lateral Hypothalamus Mediate Avoidance Behavior in Rats
Marcus M. Weera, Rosetta S. Shackett, Hannah M. Kramer, Jason W. Middleton, Nicholas W. Gilpin
Journal of Neuroscience 6 January 2021, 41 (1) 61-72; DOI: 10.1523/JNEUROSCI.0236-20.2020
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Keywords

  • avoidance
  • central amygdala
  • HCN channels
  • lateral hypothalamus
  • stress

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