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Research Articles, Cellular/Molecular

PSD-95 in CA1 Area Regulates Spatial Choice Depending on Age

Anna Cały, Małgorzata A. Śliwińska, Magdalena Ziółkowska, Kacper Łukasiewicz, Roberto Pagano, Jakub M. Dzik, Katarzyna Kalita, Tytus Bernaś, Michael G. Stewart, K. Peter Giese and Kasia Radwanska
Journal of Neuroscience 17 March 2021, 41 (11) 2329-2343; DOI: https://doi.org/10.1523/JNEUROSCI.1996-20.2020
Anna Cały
1Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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  • ORCID record for Anna Cały
Małgorzata A. Śliwińska
1Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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Magdalena Ziółkowska
1Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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Kacper Łukasiewicz
1Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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Roberto Pagano
1Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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Jakub M. Dzik
2Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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Katarzyna Kalita
3Laboratory of Neurobiology, BRAINCITY, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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Tytus Bernaś
4Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298
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Michael G. Stewart
5Department of Life, Health & Chemical Sciences, The Open University, Milton Keynes MK7 6AA, United Kingdom
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K. Peter Giese
6Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom
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Kasia Radwanska
1Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1996-20.2020
PubMed 
33472821
Published By 
Society for Neuroscience
History 
  • Received July 30, 2020
  • Revision received October 6, 2020
  • Accepted December 21, 2020
  • First published January 20, 2021.
  • Version of record published March 17, 2021.
Copyright & Usage 
Copyright © 2021 the authors SfN exclusive license.

Author Information

  1. Anna Cały1,*,
  2. Małgorzata A. Śliwińska1,*,
  3. Magdalena Ziółkowska1,
  4. Kacper Łukasiewicz1,
  5. Roberto Pagano1,
  6. Jakub M. Dzik2,
  7. Katarzyna Kalita3,
  8. Tytus Bernaś4,
  9. Michael G. Stewart5,
  10. K. Peter Giese6, and
  11. Kasia Radwanska1
  1. 1Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
  2. 2Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
  3. 3Laboratory of Neurobiology, BRAINCITY, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093, Warsaw, Poland
  4. 4Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298
  5. 5Department of Life, Health & Chemical Sciences, The Open University, Milton Keynes MK7 6AA, United Kingdom
  6. 6Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom
  • M. A. Śliwińska's present address: Laboratory of Imaging Tissue Structure and Function, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.

  • K. Łukasiewicz's present address: Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064.

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Author contributions

  1. Author contributions: M.G.S., K.P.G., and K.R. designed research; A.C., M.A.Ś., M.Z., K.Ł., and R.P. performed research; K.K. contributed unpublished reagents/analytic tools; A.C., M.A.Ś., M.Z., K.Ł., R.P., J.M.D., T.B., and K.R. analyzed data; A.C. and K.R. wrote the paper.

  2. ↵*A.C. and M.A.Ś. contributed equally to this work.

  • M. A. Śliwińska's present address: Laboratory of Imaging Tissue Structure and Function, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.

  • K. Łukasiewicz's present address: Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064.

Disclosures

    • Received July 30, 2020.
    • Revision received October 6, 2020.
    • Accepted December 21, 2020.
  • This work was supported by National Science Center (Poland) Grants 2013/08/W/NZ4/00861 and 2016/22/M/NZ4/00674 to K.R., and Grant 2015/19/N/NZ4/03611 to K.Ł. Optical microscopy experiments (confocal imaging) were performed at the Laboratory of Imaging Tissue Structure and Function, which serves as an imaging core facility at the Nencki Institute of Experimental Biology.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Kasia Radwanska at k.radwanska{at}nencki.edu.pl

Funding

  • National Science Centre (Poland)

    2013/08/W/NZ4/00861; 2016/22/M/NZ4/00674

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  • previous version (January 20, 2021).
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The Journal of Neuroscience: 41 (11)
Journal of Neuroscience
Vol. 41, Issue 11
17 Mar 2021
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PSD-95 in CA1 Area Regulates Spatial Choice Depending on Age
Anna Cały, Małgorzata A. Śliwińska, Magdalena Ziółkowska, Kacper Łukasiewicz, Roberto Pagano, Jakub M. Dzik, Katarzyna Kalita, Tytus Bernaś, Michael G. Stewart, K. Peter Giese, Kasia Radwanska
Journal of Neuroscience 17 March 2021, 41 (11) 2329-2343; DOI: 10.1523/JNEUROSCI.1996-20.2020

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PSD-95 in CA1 Area Regulates Spatial Choice Depending on Age
Anna Cały, Małgorzata A. Śliwińska, Magdalena Ziółkowska, Kacper Łukasiewicz, Roberto Pagano, Jakub M. Dzik, Katarzyna Kalita, Tytus Bernaś, Michael G. Stewart, K. Peter Giese, Kasia Radwanska
Journal of Neuroscience 17 March 2021, 41 (11) 2329-2343; DOI: 10.1523/JNEUROSCI.1996-20.2020
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Keywords

  • aging
  • CA1
  • dendritic spines
  • PSD-95
  • social interactions
  • spatial choice

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