Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Research Articles, Neurobiology of Disease

Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy

Nicholas C. Holoman, Jacob J. Aiello, Timothy D. Trobenter, Matthew J. Tarchick, Michael R. Kozlowski, Emily R. Makowski, Darryl C. De Vivo, Charandeep Singh, Jonathan E. Sears and Ivy S. Samuels
Journal of Neuroscience 7 April 2021, 41 (14) 3275-3299; https://doi.org/10.1523/JNEUROSCI.2010-20.2021
Nicholas C. Holoman
1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jacob J. Aiello
1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timothy D. Trobenter
1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew J. Tarchick
1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael R. Kozlowski
1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emily R. Makowski
1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Darryl C. De Vivo
3Department of Neurology, Columbia University Irving Medical Center, New York, New York 10032
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charandeep Singh
2Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan E. Sears
2Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ivy S. Samuels
1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
2Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2010-20.2021
PubMed 
33622781
Published By 
Society for Neuroscience
History 
  • Received July 31, 2020
  • Revision received December 16, 2020
  • Accepted February 11, 2021
  • First published February 23, 2021.
  • Version of record published April 7, 2021.
Copyright & Usage 
Copyright © 2021 the authors SfN exclusive license.

Author Information

  1. Nicholas C. Holoman1,
  2. Jacob J. Aiello1,
  3. Timothy D. Trobenter1,
  4. Matthew J. Tarchick1,
  5. Michael R. Kozlowski1,
  6. Emily R. Makowski1,
  7. Darryl C. De Vivo3,
  8. Charandeep Singh2,
  9. Jonathan E. Sears2, and
  10. Ivy S. Samuels1,2
  1. 1Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106
  2. 2Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195
  3. 3Department of Neurology, Columbia University Irving Medical Center, New York, New York 10032
  • M.J. Tarchick's present address: Department of Biology, University of Akron, Akron, Ohio 44325.

View Full Text

Author contributions

  1. Author contributions: N.C.H., J.J.A., T.D.T., M.J.T., M.R.K., E.R.M., C.S., and I.S.S. performed research; N.C.H., M.J.T., and I.S.S. analyzed data; D.C.D.V. and J.E.S. contributed unpublished reagents/analytic tools; D.C.D.V. and I.S.S. edited the paper; I.S.S. designed research; I.S.S. wrote the paper.

  • M.J. Tarchick's present address: Department of Biology, University of Akron, Akron, Ohio 44325.

Disclosures

    • Received July 31, 2020.
    • Revision received December 16, 2020.
    • Accepted February 11, 2021.
  • This work was supported by Veterans Administration Merit Award I01 BX002754-01A2 to I.S.S., National Institutes of Health R01 EY024972 to J.E.S., National Institutes of Health, National Eye Institute P30 Core Grant IP30EY025585, The Research to Prevent Blindness Unrestricted Grants, Cleveland Eye Bank Foundation awarded to the Cole Eye Institute, and Cleveland Clinic Foundation. We thank Drs. E. Dale Abel, Joshua Dunaief, and Sujata Rao for providing mice; and Dr. Neal Peachey for critical reading of the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Ivy S. Samuels at Ivy.Samuels{at}va.gov or doctoreyevy{at}gmail.com

Funding

  • U.S. Department of Veterans Affairs (VA)

    I01 BX002754-01A2
  • HHS | NIH | National Eye Institute (NEI)

    EY024972; P30 EY025585
  • Research to Prevent Blindness (RPB)

    Challenge Grant
  • Cleveland Eye Bank

    Foundation Grant
  • Cleveland Clinic Foundation (CCF)

Other Version

  • previous version (February 23, 2021).
  • You are viewing the most recent version of this article.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-06-19
to
E.g., 2025-06-19

Article usage: February 2021 to June 2025

AbstractFullPdf
Feb 2021793023
Mar 2021416024
Apr 202112249645
May 2021219229
Jun 20211092616
Jul 20211302417
Aug 202198187
Sep 20211272417
Oct 2021436240
Nov 2021366135
Dec 2021176225
Total 20213212395258
Jan 2022265832
Feb 2022134320
Mar 2022227740
Apr 202297137
May 202296447
Jun 202266051
Jul 202284430
Aug 2022113713
Sep 2022115838
Oct 2022148419
Nov 20221165
Dec 202272610
Total 2022137638342
Jan 2023135842
Feb 2023185044
Mar 2023164214
Apr 2023174513
May 202362414
Jun 2023123714
Jul 202384017
Aug 2023143422
Sep 202365432
Oct 202374418
Nov 2023103411
Dec 202364216
Total 2023133504257
Jan 2024253413
Feb 2024342931
Mar 2024143830
Apr 202483023
May 2024185327
Jun 2024195027
Jul 2024114627
Aug 2024133929
Sep 202493122
Oct 202484720
Nov 202414423
Dec 202474516
Total 2024167486288
Jan 202546431
Feb 2025105616
Mar 2025135926
Apr 202544535
May 2025125020
Jun 2025445
Total 202547278133
Total369623011278
Back to top

In this issue

The Journal of Neuroscience: 41 (14)
Journal of Neuroscience
Vol. 41, Issue 14
7 Apr 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy
Nicholas C. Holoman, Jacob J. Aiello, Timothy D. Trobenter, Matthew J. Tarchick, Michael R. Kozlowski, Emily R. Makowski, Darryl C. De Vivo, Charandeep Singh, Jonathan E. Sears, Ivy S. Samuels
Journal of Neuroscience 7 April 2021, 41 (14) 3275-3299; DOI: 10.1523/JNEUROSCI.2010-20.2021

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy
Nicholas C. Holoman, Jacob J. Aiello, Timothy D. Trobenter, Matthew J. Tarchick, Michael R. Kozlowski, Emily R. Makowski, Darryl C. De Vivo, Charandeep Singh, Jonathan E. Sears, Ivy S. Samuels
Journal of Neuroscience 7 April 2021, 41 (14) 3275-3299; DOI: 10.1523/JNEUROSCI.2010-20.2021
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • diabetic retinopathy
  • electroretinogram
  • glucose
  • photoreceptor
  • retinal pigment epithelium
  • sorbitol

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Articles

  • Regional Excitatory–Inhibitory Balance Relates to Self-Reference Effect on Recollection via the Precuneus/Posterior Cingulate Cortex–Medial Prefrontal Cortex Connectivity
  • Attention Alters Population Spatial Frequency Tuning
  • Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain
Show more Research Articles

Neurobiology of Disease

  • Threonine-53 Phosphorylation of Dopamine Transporter Dictates κ-Opioid Receptor-Mediated Locomotor Suppression, Aversion, and Cocaine Reward
  • Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages
  • The Functional Anatomy of Nociception: Effective Connectivity in Chronic Pain and Placebo Response
Show more Neurobiology of Disease
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.