Article Information
- Received August 15, 2020
- Revision received January 21, 2021
- Accepted February 20, 2021
- First published March 17, 2021.
- Version of record published May 5, 2021.
Author Information
- Qiaoling Cui1,*,
- Arin Pamukcu1,*,
- Suraj Cherian1,*,
- Isaac Y. M. Chang1,*,
- Brianna L. Berceau1,
- Harry S. Xenias1,
- Matthew H. Higgs2,
- Shivakumar Rajamanickam3,4,
- Yi Chen5,
- Xixun Du1,
- Yu Zhang1,
- Hayley McMorrow1,
- Zachary A. Abecassis1,
- Simina M. Boca6,
- Nicholas J. Justice3,4,
- Charles J. Wilson2, and
- C. Savio Chan1
- 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago 60611, Illinois
- 2Department of Biology, University of Texas at San Antonio, San Antonio 78249, Texas
- 3Center for Metabolic and degenerative disease, Institute of Molecular Medicine, University of Texas, Houston 77030, Texas
- 4Department of Integrative Pharmacology, University of Texas, Houston 77030, Texas
- 5Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison 53706, Wisconsin
- 6Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington 20057, DC
Author contributions
Author contributions: S.C. and B.L.B. performed histological analysis. S.C., Q.C., I.Y.M.C., H.S.X., Y.Z., H.M., Z.A.A., and X.D. surveyed the intrinsic properties. Q.C., M.H.H., X.D., Y.Z., and C.J.W. examined the local connectivity. A.P., Q.C., S.R., and N.J.J. conducted the behavioral studies. I.Y.M.C. developed the machine learning analysis pipeline. Y.C. and S.M.B provided expertise for neuron classification. C.S.C. wrote the manuscript with input from all co-authors. All authors reviewed and edited the manuscript. C.S.C. designed, directed, and supervised the project.
↵*Q.C., A.P., S.C., and I.Y.M.C. contributed equally to this work.
Disclosures
- Received August 15, 2020.
- Revision received January 21, 2021.
- Accepted February 20, 2021.
This work was supported by National Institutes of Health R01 NS069777, R01 MH112768, R01 NS097901, R01 MH109466, and R01 NS088528 to C.S.C., T32 AG020506 to A.P., T32 NS041234 and F32 NS098793 to H.S.X., R01 MH112768 to N.J.J., R35 NS097185 to C.J.W., and HHMI-PF Medical Research Fellowship and AΩA Student Research Fellowship to Z.A.A. We thank Daniela Garcia, Alyssa Bebenek, Moises Melesio, Kris Shah, Ahana Narayanan, Vaishnavi Tetali, Saivasudha Chalasani, and Daniel Hegeman for assistance on the project; Dr. Tiffany Schmidt for providing Kcng4-Cre mice; Dr. Byung Kook Lim for providing the synaptophysin-GFP virus; and Drs. Ann Kennedy and Sam Golden for input on the behavioral analyses.
The authors declare no competing financial interests.
- Correspondence should be addressed to C. Savio Chan at saviochan{at}gmail.com
Funding
National Institute of Health
NS069777; MH112768; NS097901; MH109466; NS088528; AG020506; NS041234; NS098793; MH112768; NS097185Howard Hughes Medical Institute (HHMI)
AΩA Student Research Fellowship
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