This image demonstrates tau-reporter aggregation induced by exposure to misfolded tau seeds in neurons derived from induced pluripotent stem cells generated at the time of autopsy from an Alzheimer disease patient harboring the L435F allele of presenilin1. Red represents a tau aggregation sensor. Cyan represents endogenous phosphorylated tau protein. Yellow represents nuclei. For more information, see the article by Oakley et al. (pages 4335–4348). Cover image: Derek H. Oakley.