Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice

Christian M. Simon; Beatriz Blanco-Redondo; Jannik M. Buettner; John G. Pagiazitis; Emily V. Fletcher; Josiane K. Sime Longang; George Z. Mentis

doi:10.1523/JNEUROSCI.2142-20.2020

Research Articles, Neurobiology of Disease

Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice

Christian M. Simon, Beatriz Blanco-Redondo, Jannik M. Buettner, John G. Pagiazitis, Emily V. Fletcher, Josiane K. Sime Longang and George Z. Mentis

Journal of Neuroscience 13 January 2021, 41 (2) 376-389; DOI: https://doi.org/10.1523/JNEUROSCI.2142-20.2020

Christian M. Simon

1Carl-Ludwig-Institute for Physiology, Leipzig University, Leipzig 04103, Germany

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Beatriz Blanco-Redondo

2Rudolf-Schönheimer Institute for Biochemistry, Leipzig University, Leipzig 04103, Germany

3Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032

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Jannik M. Buettner

1Carl-Ludwig-Institute for Physiology, Leipzig University, Leipzig 04103, Germany

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John G. Pagiazitis

3Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032

4Departments of Pathology and Cell Biology and Neurology, Columbia University, New York, New York 10032

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Emily V. Fletcher

3Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032

4Departments of Pathology and Cell Biology and Neurology, Columbia University, New York, New York 10032

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Josiane K. Sime Longang

1Carl-Ludwig-Institute for Physiology, Leipzig University, Leipzig 04103, Germany

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George Z. Mentis

3Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032

4Departments of Pathology and Cell Biology and Neurology, Columbia University, New York, New York 10032

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Journal of Neuroscience

Vol. 41, Issue 2

13 Jan 2021

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Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice

Christian M. Simon, Beatriz Blanco-Redondo, Jannik M. Buettner, John G. Pagiazitis, Emily V. Fletcher, Josiane K. Sime Longang, George Z. Mentis

Journal of Neuroscience 13 January 2021, 41 (2) 376-389; DOI: 10.1523/JNEUROSCI.2142-20.2020

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Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice

Christian M. Simon, Beatriz Blanco-Redondo, Jannik M. Buettner, John G. Pagiazitis, Emily V. Fletcher, Josiane K. Sime Longang, George Z. Mentis

Journal of Neuroscience 13 January 2021, 41 (2) 376-389; DOI: 10.1523/JNEUROSCI.2142-20.2020

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Keywords

motor neuron death
neurodegeneration
neuronal activity
sensory-motor circuit
spinal muscular atrophy
synaptic dysfunction

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