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In this confocal image, the projection neurons from the entorhinal cortex are labeled with an antibody against mCherry (cyan). The neurons were targeted using neonatal injection of an adenoassociated virus expressing chemogenetic hM4D(Gi) receptors. This technique allows the chronic silencing of the main excitatory inputs in the hippocampus during postnatal development. For more information, see the article by Feng et al. (pages 4607–4619). Cover image: Simon Pieraut.