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Research Articles, Neurobiology of Disease

VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration

Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre and Zachary Freyberg
Journal of Neuroscience 2 June 2021, 41 (22) 4937-4947; DOI: https://doi.org/10.1523/JNEUROSCI.2770-20.2021
Silas A. Buck
1Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
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  • ORCID record for Silas A. Buck
Briana R. De Miranda
3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
4Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, 35294
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Ryan W. Logan
5Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, 02118
6Center for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, Maine, 04609
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Kenneth N. Fish
2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
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J. Timothy Greenamyre
3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
7Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
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Zachary Freyberg
2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
8Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2770-20.2021
PubMed 
33893220
Published By 
Society for Neuroscience
History 
  • Received October 30, 2020
  • Revision received April 13, 2021
  • Accepted April 15, 2021
  • First published April 23, 2021.
  • Version of record published June 2, 2021.
Copyright & Usage 
Copyright © 2021 the authors SfN exclusive license.

Author Information

  1. Silas A. Buck1,2,*,
  2. Briana R. De Miranda3,4,*,
  3. Ryan W. Logan5,6,
  4. Kenneth N. Fish2,
  5. J. Timothy Greenamyre3,7, and
  6. Zachary Freyberg2,8
  1. 1Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
  2. 2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
  3. 3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
  4. 4Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, 35294
  5. 5Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, 02118
  6. 6Center for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, Maine, 04609
  7. 7Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
  8. 8Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
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Author contributions

  1. Author contributions: S.A.B., B.R.D.M., K.N.F., J.T.G., and Z.F. designed research; S.A.B., B.R.D.M., and K.N.F. performed research; S.A.B., B.R.D.M., R.W.L., K.N.F., and Z.F. analyzed data; S.A.B., B.R.D.M., and Z.F. wrote the first draft of the paper; S.A.B., B.R.D.M., R.W.L., K.N.F., J.T.G., and Z.F. edited the paper; S.A.B., B.R.D.M., J.T.G., and Z.F. wrote the paper; K.N.F. contributed unpublished reagents/analytic tools.

  2. ↵*S.A.B. and B.R.D.M. contributed equally to this work.

Disclosures

    • Received October 30, 2020.
    • Revision received April 13, 2021.
    • Accepted April 15, 2021.
  • This work was supported in part by National Institutes of Health Grant R21AG068607 to Z.F. and Grant K99ES029986 to B.R.D.M., the John F. and Nancy A. Emmerling Fund of the Pittsburgh Foundation to Z.F., and the American Parkinson Disease Association Center for Advanced Research at the University of Pittsburgh to J.T.G. We thank Drs. Thomas Hnasko and Thomas Steinkellner for helpful discussions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Zachary Freyberg at freyberg{at}pitt.edu

Funding

  • NIH/NIA

    R21AG068607
  • NIH/NIEHS

    K99ES029986
  • John F. and Nancy A. Emmerling Fund of The Pittsburgh Foundation

  • American Parkinson Disease Association Center for Advanced Research at the University of Pittsburgh

Other Version

  • previous version (April 23, 2021).
  • You are viewing the most recent version of this article.

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Apr 20211209082
May 2021585051
Jun 2021114118691
Jul 20212944015
Aug 20211753516
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The Journal of Neuroscience: 41 (22)
Journal of Neuroscience
Vol. 41, Issue 22
2 Jun 2021
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VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration
Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre, Zachary Freyberg
Journal of Neuroscience 2 June 2021, 41 (22) 4937-4947; DOI: 10.1523/JNEUROSCI.2770-20.2021

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VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration
Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre, Zachary Freyberg
Journal of Neuroscience 2 June 2021, 41 (22) 4937-4947; DOI: 10.1523/JNEUROSCI.2770-20.2021
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Keywords

  • dopamine
  • glutamate
  • neurodegeneration
  • rotenone
  • tyrosine hydroxylase
  • VGLUT2

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