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Research Articles, Neurobiology of Disease

VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration

Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre and Zachary Freyberg
Journal of Neuroscience 2 June 2021, 41 (22) 4937-4947; DOI: https://doi.org/10.1523/JNEUROSCI.2770-20.2021
Silas A. Buck
1Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
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Briana R. De Miranda
3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
4Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, 35294
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Ryan W. Logan
5Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, 02118
6Center for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, Maine, 04609
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Kenneth N. Fish
2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
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J. Timothy Greenamyre
3Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
7Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
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Zachary Freyberg
2Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
8Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213
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The Journal of Neuroscience: 41 (22)
Journal of Neuroscience
Vol. 41, Issue 22
2 Jun 2021
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VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration
Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre, Zachary Freyberg
Journal of Neuroscience 2 June 2021, 41 (22) 4937-4947; DOI: 10.1523/JNEUROSCI.2770-20.2021

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VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration
Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre, Zachary Freyberg
Journal of Neuroscience 2 June 2021, 41 (22) 4937-4947; DOI: 10.1523/JNEUROSCI.2770-20.2021
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Keywords

  • dopamine
  • glutamate
  • neurodegeneration
  • rotenone
  • tyrosine hydroxylase
  • VGLUT2

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