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Research Articles, Cellular/Molecular

G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch

Ting Gao, Li Dong, Jiahong Qian, Xiaowei Ding, Yi Zheng, Meimei Wu, Li Meng, Yingfu Jiao, Po Gao, Ping Luo, Guohua Zhang, Changhao Wu, Xueyin Shi and Weifang Rong
Journal of Neuroscience 15 September 2021, 41 (37) 7727-7741; DOI: https://doi.org/10.1523/JNEUROSCI.2592-20.2021
Ting Gao
1Department of Anesthesiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Li Dong
1Department of Anesthesiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Jiahong Qian
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
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Xiaowei Ding
1Department of Anesthesiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Yi Zheng
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Meimei Wu
1Department of Anesthesiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Li Meng
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Yingfu Jiao
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
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Po Gao
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
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  • ORCID record for Po Gao
Ping Luo
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Guohua Zhang
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Changhao Wu
4School of Biosciences and Medicine, University of Surrey, Guildford, Surrey GU2 7XH, England
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Xueyin Shi
1Department of Anesthesiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
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Weifang Rong
1Department of Anesthesiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2592-20.2021
PubMed 
34349001
Published By 
Society for Neuroscience
History 
  • Received October 7, 2020
  • Revision received July 19, 2021
  • Accepted July 28, 2021
  • First published August 4, 2021.
  • Version of record published September 15, 2021.
Copyright & Usage 
Copyright © 2021 the authors SfN exclusive license.

Author Information

  1. Ting Gao1,2,*,
  2. Li Dong1,2,*,
  3. Jiahong Qian2,3,*,
  4. Xiaowei Ding1,2,
  5. Yi Zheng2,
  6. Meimei Wu1,2,
  7. Li Meng2,
  8. Yingfu Jiao2,3,
  9. Po Gao2,3,
  10. Ping Luo2,
  11. Guohua Zhang2,
  12. Changhao Wu4,
  13. Xueyin Shi1, and
  14. Weifang Rong1,2
  1. 1Department of Anesthesiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  2. 2Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  3. 3Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  4. 4School of Biosciences and Medicine, University of Surrey, Guildford, Surrey GU2 7XH, England
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Author contributions

  1. Author contributions: T.G., L.D., G.Z., C.W., X.S., and W.R. designed research; T.G., J.Q., X.D., Y.Z., M.W., L.M., Y.J., P.G., and P.L. performed research; T.G., J.Q., and W.R. analyzed data; W.R. wrote the paper.

  2. ↵*T.G., L.D., and J.Q. contributed equally to this work.

Disclosures

    • Received October 7, 2020.
    • Revision received July 19, 2021.
    • Accepted July 28, 2021.
  • This work was supported by the National Natural Science Foundation of China (Grants 81570493 and 81873728), the Science and Technology Commission of Shanghai Municipality (Grant 18JC1420302), and Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (Grant JZPI201705). C.W. was supported by the Biotechnology and Biological Sciences Research Council (BB/P004695/1) and National Institute of Aging (1R01AG049321-01A1).

  • The authors declare no competing interests.

  • Correspondence should be addressed to Weifang Rong at weifangrong{at}shsmu.edu.cn or Xueyin Shi at shixueyin1128{at}163.com

Funding

  • The National Natural Science Foundation of China

    81873728;81570493
  • The Science and Technology Commission of Shanghai Municipality

    18JC1420302
  • Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

    JZPI201705
  • Biotechnology and Biological Sciences Research Council (BBSRC)

    BB/P004695/1

Other Version

  • previous version (August 04, 2021).
  • You are viewing the most recent version of this article.

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AbstractFullPdf
Aug 2021435028
Sep 2021106512878
Oct 20213384120
Nov 20211894719
Dec 202115131612
Total 20212178532157
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Feb 20221003111
Mar 2022713819
Apr 2022218931
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Total 2022460594226
Jan 2023223412
Total 2023223412
Total26601160395
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The Journal of Neuroscience: 41 (37)
Journal of Neuroscience
Vol. 41, Issue 37
15 Sep 2021
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G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch
Ting Gao, Li Dong, Jiahong Qian, Xiaowei Ding, Yi Zheng, Meimei Wu, Li Meng, Yingfu Jiao, Po Gao, Ping Luo, Guohua Zhang, Changhao Wu, Xueyin Shi, Weifang Rong
Journal of Neuroscience 15 September 2021, 41 (37) 7727-7741; DOI: 10.1523/JNEUROSCI.2592-20.2021

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G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch
Ting Gao, Li Dong, Jiahong Qian, Xiaowei Ding, Yi Zheng, Meimei Wu, Li Meng, Yingfu Jiao, Po Gao, Ping Luo, Guohua Zhang, Changhao Wu, Xueyin Shi, Weifang Rong
Journal of Neuroscience 15 September 2021, 41 (37) 7727-7741; DOI: 10.1523/JNEUROSCI.2592-20.2021
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Keywords

  • µ type opioid receptor
  • G-protein-coupled estrogen receptor
  • itch
  • rostral ventromedial medulla

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