Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis

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¹Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089
²Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089
³Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892

Author contributions: C.T., J.D.P., and B.E.H. designed research; C.T. performed electrophysiology and imaging experiments; J.D.P. and E.F. performed biochemical experiments; C.T., J.D.P., and E.F. analyzed data; C.T., J.D.P., E.F., K.W.R., and B.E.H. wrote and edited the paper.
↵*C.T. and J.D.P. contributed equally to this work as co-first authors.

This work was supported by the Brain and Behavior Research Foundation to B.E.H., the Simons Foundation to B.E.H., the McKnight Foundation to B.E.H., National Institute of Mental Health R00MH103398 to B.E.H., and National Institute of Neurological Disorders and Stroke R01NS112480 to B.E.H. Funds supporting this work were also provided by a University of Southern California Theodore and Wen-Hui Chen Endowed Fellowship to C.T., and the National Institute of Neurological Disorders and Stroke Intramural Research Program to J.D.P., E.F., and K.W.R. We thank members of B.E.H. and K.W.R. laboratories for helpful feedback during the study.
The authors declare no competing financial interests.
Correspondence should be addressed to Bruce E. Herring at bherring{at}usc.edu

HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
R01NS112480
HHS | NIH | National Institute of Mental Health (NIMH)
R00MH103398
Simons Foundation
McKnight Endowment Fund for Neuroscience
Wen-Hui Chen Endowed Fellowship, University of Southern California

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